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Disabling c-Myc in childhood medulloblastoma and atypical teratoid/rhabdoid tumor cells by the potent G-quadruplex interactive agent S2T1-6OTD.
Shalaby T, von Bueren AO, Hürlimann ML, Fiaschetti G, Castelletti D, Masayuki T, Nagasawa K, Arcaro A, Jelesarov I, Shin-ya K, Grotzer M. Shalaby T, et al. Among authors: fiaschetti g. Mol Cancer Ther. 2010 Jan;9(1):167-79. doi: 10.1158/1535-7163.MCT-09-0586. Epub 2010 Jan 6. Mol Cancer Ther. 2010. PMID: 20053783
The quassinoid derivative NBT-272 targets both the AKT and ERK signaling pathways in embryonal tumors.
Castelletti D, Fiaschetti G, Di Dato V, Ziegler U, Kumps C, De Preter K, Zollo M, Speleman F, Shalaby T, De Martino D, Berg T, Eggert A, Arcaro A, Grotzer MA. Castelletti D, et al. Among authors: fiaschetti g. Mol Cancer Ther. 2010 Dec;9(12):3145-57. doi: 10.1158/1535-7163.MCT-10-0539. Epub 2010 Oct 1. Mol Cancer Ther. 2010. PMID: 20889731 Free article.
MicroRNA-21 suppression impedes medulloblastoma cell migration.
Grunder E, D'Ambrosio R, Fiaschetti G, Abela L, Arcaro A, Zuzak T, Ohgaki H, Lv SQ, Shalaby T, Grotzer M. Grunder E, et al. Among authors: fiaschetti g. Eur J Cancer. 2011 Nov;47(16):2479-90. doi: 10.1016/j.ejca.2011.06.041. Epub 2011 Jul 19. Eur J Cancer. 2011. PMID: 21775132
G-quadruplexes as potential therapeutic targets for embryonal tumors.
Shalaby T, Fiaschetti G, Nagasawa K, Shin-ya K, Baumgartner M, Grotzer M. Shalaby T, et al. Among authors: fiaschetti g. Molecules. 2013 Oct 10;18(10):12500-37. doi: 10.3390/molecules181012500. Molecules. 2013. PMID: 24152672 Free PMC article. Review.
14 results