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Page 1
Morpholine containing CB2 selective agonists.
Zindell R, Riether D, Bosanac T, Berry A, Gemkow MJ, Ebneth A, Löbbe S, Raymond EL, Thome D, Shih DT, Thomson D. Zindell R, et al. Among authors: shih dt. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1604-9. doi: 10.1016/j.bmcl.2009.02.033. Epub 2009 Feb 12. Bioorg Med Chem Lett. 2009. PMID: 19243942
Arylsulfonamide CB2 receptor agonists: SAR and optimization of CB2 selectivity.
Ermann M, Riether D, Walker ER, Mushi IF, Jenkins JE, Noya-Marino B, Brewer ML, Taylor MG, Amouzegh P, East SP, Dymock BW, Gemkow MJ, Kahrs AF, Ebneth A, Löbbe S, O'Shea K, Shih DT, Thomson D. Ermann M, et al. Among authors: shih dt. Bioorg Med Chem Lett. 2008 Mar 1;18(5):1725-9. doi: 10.1016/j.bmcl.2008.01.042. Epub 2008 Jan 18. Bioorg Med Chem Lett. 2008. PMID: 18255291
1,4-Diazepane compounds as potent and selective CB2 agonists: optimization of metabolic stability.
Riether D, Wu L, Cirillo PF, Berry A, Walker ER, Ermann M, Noya-Marino B, Jenkins JE, Albaugh D, Albrecht C, Fisher M, Gemkow MJ, Grbic H, Löbbe S, Möller C, O'Shea K, Sauer A, Shih DT, Thomson DS. Riether D, et al. Among authors: shih dt. Bioorg Med Chem Lett. 2011 Apr 1;21(7):2011-6. doi: 10.1016/j.bmcl.2011.02.017. Epub 2011 Feb 25. Bioorg Med Chem Lett. 2011. PMID: 21354795
Aryl 1,4-diazepane compounds as potent and selective CB2 agonists: optimization of drug-like properties and target independent parameters.
Zindell R, Walker ER, Scott J, Amouzegh P, Wu L, Ermann M, Thomson D, Fisher MB, Fullenwider CL, Grbic H, Kaplita P, Linehan B, Patel M, Patel M, Löbbe S, Block S, Albrecht C, Gemkow MJ, Shih DT, Riether D. Zindell R, et al. Among authors: shih dt. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4276-80. doi: 10.1016/j.bmcl.2011.05.068. Epub 2011 May 27. Bioorg Med Chem Lett. 2011. PMID: 21689933
Trifluoromethyl group as a pharmacophore: effect of replacing a CF3 group on binding and agonist activity of a glucocorticoid receptor ligand.
Betageri R, Zhang Y, Zindell RM, Kuzmich D, Kirrane TM, Bentzien J, Cardozo M, Capolino AJ, Fadra TN, Nelson RM, Paw Z, Shih DT, Shih CK, Zuvela-Jelaska L, Nabozny G, Thomson DS. Betageri R, et al. Among authors: shih dt, shih ck. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4761-9. doi: 10.1016/j.bmcl.2005.07.025. Bioorg Med Chem Lett. 2005. PMID: 16112571
Exploration of cathepsin S inhibitors characterized by a triazole P1-P2 amide replacement.
Moss N, Xiong Z, Burke M, Cogan D, Gao DA, Haverty K, Heim-Riether A, Hickey ER, Nagaraja R, Netherton M, O'Shea K, Ramsden P, Schwartz R, Shih DT, Ward Y, Young E, Zhang Q. Moss N, et al. Among authors: shih dt. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7189-93. doi: 10.1016/j.bmcl.2012.09.054. Epub 2012 Oct 2. Bioorg Med Chem Lett. 2012. PMID: 23084902
56 results