Keppler BK - Search Results

1

Pharmacokinetics of a novel anticancer ruthenium complex (KP1019, FFC14A) in a phase I dose-escalation study.

Lentz F, Drescher A, Lindauer A, Henke M, Hilger RA, Hartinger CG, Scheulen ME, Dittrich C, Keppler BK, Jaehde U; Central European Society for Anticancer Drug Research-EWIV. Lentz F, et al. Among authors: keppler bk. Anticancer Drugs. 2009 Feb;20(2):97-103. doi: 10.1097/CAD.0b013e328322fbc5. Anticancer Drugs. 2009. PMID: 19209025 Clinical Trial.

2

From bench to bedside--preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A).

Hartinger CG, Zorbas-Seifried S, Jakupec MA, Kynast B, Zorbas H, Keppler BK. Hartinger CG, et al. Among authors: keppler bk. J Inorg Biochem. 2006 May;100(5-6):891-904. doi: 10.1016/j.jinorgbio.2006.02.013. Epub 2006 Feb 28. J Inorg Biochem. 2006. PMID: 16603249 Review.

3

Effect of reactivity on cellular accumulation and cytotoxicity of oxaliplatin analogues.

Buß I, Kalayda GV, Lindauer A, Reithofer MR, Galanski MS, Keppler BK, Jaehde U. Buß I, et al. Among authors: keppler bk. J Biol Inorg Chem. 2012 Jun;17(5):699-708. doi: 10.1007/s00775-012-0889-9. Epub 2012 Mar 29. J Biol Inorg Chem. 2012. PMID: 22456982

4

Characterization of the binding sites of the anticancer ruthenium(III) complexes KP1019 and KP1339 on human serum albumin via competition studies.

Dömötör O, Hartinger CG, Bytzek AK, Kiss T, Keppler BK, Enyedy EA. Dömötör O, et al. Among authors: keppler bk. J Biol Inorg Chem. 2013 Jan;18(1):9-17. doi: 10.1007/s00775-012-0944-6. Epub 2012 Oct 18. J Biol Inorg Chem. 2013. PMID: 23076343

5

Platinum group metallodrug-protein binding studies by capillary electrophoresis - inductively coupled plasma-mass spectrometry: a further insight into the reactivity of a novel antitumor ruthenium(III) complex toward human serum proteins.

Polec-Pawlak K, Abramski JK, Semenova O, Hartinger CG, Timerbaev AR, Keppler BK, Jarosz M. Polec-Pawlak K, et al. Among authors: keppler bk. Electrophoresis. 2006 Mar;27(5-6):1128-35. doi: 10.1002/elps.200500694. Electrophoresis. 2006. PMID: 16440400

6

CE in anticancer metallodrug research--an update.

Hartinger CG, Keppler BK. Hartinger CG, et al. Among authors: keppler bk. Electrophoresis. 2007 Oct;28(19):3436-46. doi: 10.1002/elps.200700114. Electrophoresis. 2007. PMID: 17847132 Review.

7

CZE-ICP-MS as a tool for studying the hydrolysis of ruthenium anticancer drug candidates and their reactivity towards the DNA model compound dGMP.

Groessl M, Hartinger CG, Dyson PJ, Keppler BK. Groessl M, et al. Among authors: keppler bk. J Inorg Biochem. 2008 May-Jun;102(5-6):1060-5. doi: 10.1016/j.jinorgbio.2007.11.018. Epub 2007 Dec 14. J Inorg Biochem. 2008. PMID: 18222004

8

Capillary electrophoresis hyphenated to inductively coupled plasma-mass spectrometry: a novel approach for the analysis of anticancer metallodrugs in human serum and plasma.

Groessl M, Hartinger CG, Polec-Pawlak K, Jarosz M, Keppler BK. Groessl M, et al. Among authors: keppler bk. Electrophoresis. 2008 May;29(10):2224-32. doi: 10.1002/elps.200780790. Electrophoresis. 2008. PMID: 18512673 Clinical Trial.

9

Elucidation of the interactions of an anticancer ruthenium complex in clinical trials with biomolecules utilizing capillary electrophoresis hyphenated to inductively coupled plasma-mass spectrometry. Short communication.

Groessl M, Hartinger CG, Połeć-Pawlak K, Jarosz M, Dyson PJ, Keppler BK. Groessl M, et al. Among authors: keppler bk. Chem Biodivers. 2008 Aug;5(8):1609-1614. doi: 10.1002/cbdv.200890148. Chem Biodivers. 2008. PMID: 18729095

10

KP1019, a new redox-active anticancer agent--preclinical development and results of a clinical phase I study in tumor patients.

Hartinger CG, Jakupec MA, Zorbas-Seifried S, Groessl M, Egger A, Berger W, Zorbas H, Dyson PJ, Keppler BK. Hartinger CG, et al. Among authors: keppler bk. Chem Biodivers. 2008 Oct;5(10):2140-2155. doi: 10.1002/cbdv.200890195. Chem Biodivers. 2008. PMID: 18972504 Review.

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