Read KD - Search Results

1

Receptor occupancy and brain free fraction.

Watson J, Wright S, Lucas A, Clarke KL, Viggers J, Cheetham S, Jeffrey P, Porter R, Read KD. Watson J, et al. Among authors: read kd. Drug Metab Dispos. 2009 Apr;37(4):753-60. doi: 10.1124/dmd.108.022814. Epub 2009 Jan 21. Drug Metab Dispos. 2009. PMID: 19158315

2

The relationship between sodium channel inhibition and anticonvulsant activity in a model of generalised seizure in the rat.

Large CH, Kalinichev M, Lucas A, Carignani C, Bradford A, Garbati N, Sartori I, Austin NE, Ruffo A, Jones DN, Alvaro G, Read KD. Large CH, et al. Among authors: read kd. Epilepsy Res. 2009 Jul;85(1):96-106. doi: 10.1016/j.eplepsyres.2009.02.018. Epub 2009 Mar 28. Epilepsy Res. 2009. PMID: 19329281

3

Potentiation of the anticonvulsant efficacy of sodium channel inhibitors by an NK1-receptor antagonist in the rat.

Kalinichev M, Bradford A, Bison S, Lucas A, Sartori I, Garbati N, Andreetta F, Bate S, Austin NE, Jones DN, Read KD, Alvaro G, Large CH. Kalinichev M, et al. Among authors: read kd. Epilepsia. 2010 Aug;51(8):1543-51. doi: 10.1111/j.1528-1167.2009.02482.x. Epub 2010 Jan 7. Epilepsia. 2010. PMID: 20067506 Free article.

4

Assessing brain free fraction in early drug discovery.

Read KD, Braggio S. Read KD, et al. Expert Opin Drug Metab Toxicol. 2010 Mar;6(3):337-44. doi: 10.1517/17425250903559873. Expert Opin Drug Metab Toxicol. 2010. PMID: 20102287 Review.

5

Combining PET biodistribution and equilibrium dialysis assays to assess the free brain concentration and BBB transport of CNS drugs.

Gunn RN, Summerfield SG, Salinas CA, Read KD, Guo Q, Searle GE, Parker CA, Jeffrey P, Laruelle M. Gunn RN, et al. Among authors: read kd. J Cereb Blood Flow Metab. 2012 May;32(5):874-83. doi: 10.1038/jcbfm.2012.1. Epub 2012 Jan 25. J Cereb Blood Flow Metab. 2012. PMID: 22274741 Free PMC article.

6

The systemic exposure of an N-methyl-D-aspartate receptor antagonist is limited in mice by the P-glycoprotein and breast cancer resistance protein efflux transporters.

Polli JW, Baughman TM, Humphreys JE, Jordan KH, Mote AL, Webster LO, Barnaby RJ, Vitulli G, Bertolotti L, Read KD, Serabjit-Singh CJ. Polli JW, et al. Among authors: read kd. Drug Metab Dispos. 2004 Jul;32(7):722-6. doi: 10.1124/dmd.32.7.722. Drug Metab Dispos. 2004. PMID: 15205387

7

A comparative study of the CYP450 inhibition potential of marketed drugs using two fluorescence based assay platforms routinely used in the pharmaceutical industry.

Kajbaf M, Longhi R, Montanari D, Vinco F, Rigo M, Fontana S, Read KD. Kajbaf M, et al. Among authors: read kd. Drug Metab Lett. 2011 Jan;5(1):30-9. doi: 10.2174/187231211794455262. Drug Metab Lett. 2011. PMID: 21198439

8

Automated design of ligands to polypharmacological profiles.

Besnard J, Ruda GF, Setola V, Abecassis K, Rodriguiz RM, Huang XP, Norval S, Sassano MF, Shin AI, Webster LA, Simeons FR, Stojanovski L, Prat A, Seidah NG, Constam DB, Bickerton GR, Read KD, Wetsel WC, Gilbert IH, Roth BL, Hopkins AL. Besnard J, et al. Among authors: read kd. Nature. 2012 Dec 13;492(7428):215-20. doi: 10.1038/nature11691. Nature. 2012. PMID: 23235874 Free PMC article.

9

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.

Frearson JA, Brand S, McElroy SP, Cleghorn LA, Smid O, Stojanovski L, Price HP, Guther ML, Torrie LS, Robinson DA, Hallyburton I, Mpamhanga CP, Brannigan JA, Wilkinson AJ, Hodgkinson M, Hui R, Qiu W, Raimi OG, van Aalten DM, Brenk R, Gilbert IH, Read KD, Fairlamb AH, Ferguson MA, Smith DF, Wyatt PG. Frearson JA, et al. Among authors: read kd. Nature. 2010 Apr 1;464(7289):728-32. doi: 10.1038/nature08893. Nature. 2010. PMID: 20360736 Free PMC article.

10

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis.

Jones DC, Hallyburton I, Stojanovski L, Read KD, Frearson JA, Fairlamb AH. Jones DC, et al. Among authors: read kd. Biochem Pharmacol. 2010 Nov 15;80(10):1478-86. doi: 10.1016/j.bcp.2010.07.038. Epub 2010 Aug 7. Biochem Pharmacol. 2010. PMID: 20696141 Free PMC article.

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