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In vitro assays for induction of drug metabolism.
Lake BG, Price RJ, Giddings AM, Walters DG. Lake BG, et al. Among authors: giddings am. Methods Mol Biol. 2009;481:47-58. doi: 10.1007/978-1-59745-201-4_5. Methods Mol Biol. 2009. PMID: 19096794 Review.
Skin sensitization in silico protocol.
Johnson C, Ahlberg E, Anger LT, Beilke L, Benigni R, Bercu J, Bobst S, Bower D, Brigo A, Campbell S, Cronin MTD, Crooks I, Cross KP, Doktorova T, Exner T, Faulkner D, Fearon IM, Fehr M, Gad SC, Gervais V, Giddings A, Glowienke S, Hardy B, Hasselgren C, Hillegass J, Jolly R, Krupp E, Lomnitski L, Magby J, Mestres J, Milchak L, Miller S, Muster W, Neilson L, Parakhia R, Parenty A, Parris P, Paulino A, Paulino AT, Roberts DW, Schlecker H, Stidl R, Suarez-Rodrigez D, Szabo DT, Tice RR, Urbisch D, Vuorinen A, Wall B, Weiler T, White AT, Whritenour J, Wichard J, Woolley D, Zwickl C, Myatt GJ. Johnson C, et al. Regul Toxicol Pharmacol. 2020 Oct;116:104688. doi: 10.1016/j.yrtph.2020.104688. Epub 2020 Jul 1. Regul Toxicol Pharmacol. 2020. PMID: 32621976 Free PMC article.
It's difficult, but important, to make negative predictions.
Williams RV, Amberg A, Brigo A, Coquin L, Giddings A, Glowienke S, Greene N, Jolly R, Kemper R, O'Leary-Steele C, Parenty A, Spirkl HP, Stalford SA, Weiner SK, Wichard J. Williams RV, et al. Regul Toxicol Pharmacol. 2016 Apr;76:79-86. doi: 10.1016/j.yrtph.2016.01.008. Epub 2016 Jan 16. Regul Toxicol Pharmacol. 2016. PMID: 26785392
Considerations when deriving compound-specific limits for extractables and leachables from pharmaceutical products: Four case studies.
Parris P, Martin EA, Stanard B, Glowienke S, Dolan DG, Li K, Binazon O, Giddings A, Whelan G, Masuda-Herrera M, Bercu J, Broschard T, Bruen U, Callis CM, Stults CLM, Erexson GL, Cruz MT, Nagao LM. Parris P, et al. Regul Toxicol Pharmacol. 2020 Dec;118:104802. doi: 10.1016/j.yrtph.2020.104802. Epub 2020 Oct 7. Regul Toxicol Pharmacol. 2020. PMID: 33038429
Managing emerging mutagenicity risks: Late stage mutagenic impurity control within the atovaquone second generation synthesis.
Urquhart MWJ, Bardsley B, Edwards AJ, Giddings A, Griva E, Harvey J, Hermitage S, King F, Leach S, Lesurf C, McKinlay C, Oxley P, Pham TN, Simpson A, Smith E, Stevenson N, Wade C, White A, Wooster N. Urquhart MWJ, et al. Regul Toxicol Pharmacol. 2018 Nov;99:22-32. doi: 10.1016/j.yrtph.2018.08.004. Epub 2018 Aug 15. Regul Toxicol Pharmacol. 2018. PMID: 30118726
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