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Carteriosulfonic acids A-C, GSK-3beta inhibitors from a Carteriospongia sp.
McCulloch MW, Bugni TS, Concepcion GP, Coombs GS, Harper MK, Kaur S, Mangalindan GC, Mutizwa MM, Veltri CA, Virshup DM, Ireland CM. McCulloch MW, et al. Among authors: virshup dm. J Nat Prod. 2009 Sep;72(9):1651-6. doi: 10.1021/np900336f. J Nat Prod. 2009. PMID: 19778090 Free PMC article.
WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification.
Coombs GS, Yu J, Canning CA, Veltri CA, Covey TM, Cheong JK, Utomo V, Banerjee N, Zhang ZH, Jadulco RC, Concepcion GP, Bugni TS, Harper MK, Mihalek I, Jones CM, Ireland CM, Virshup DM. Coombs GS, et al. Among authors: virshup dm. J Cell Sci. 2010 Oct 1;123(Pt 19):3357-67. doi: 10.1242/jcs.072132. Epub 2010 Sep 7. J Cell Sci. 2010. PMID: 20826466 Free PMC article.
Modulation of Wnt/β-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer.
Coombs GS, Schmitt AA, Canning CA, Alok A, Low IC, Banerjee N, Kaur S, Utomo V, Jones CM, Pervaiz S, Toone EJ, Virshup DM. Coombs GS, et al. Among authors: virshup dm. Oncogene. 2012 Jan 12;31(2):213-25. doi: 10.1038/onc.2011.228. Epub 2011 Jun 13. Oncogene. 2012. PMID: 21666721 Free PMC article.
Regulation of casein kinase I epsilon activity by Wnt signaling.
Swiatek W, Tsai IC, Klimowski L, Pepler A, Barnette J, Yost HJ, Virshup DM. Swiatek W, et al. Among authors: virshup dm. J Biol Chem. 2004 Mar 26;279(13):13011-7. doi: 10.1074/jbc.M304682200. Epub 2004 Jan 13. J Biol Chem. 2004. PMID: 14722104 Free article.
Discovery and Optimization of a Porcupine Inhibitor.
Duraiswamy AJ, Lee MA, Madan B, Ang SH, Tan ES, Cheong WW, Ke Z, Pendharkar V, Ding LJ, Chew YS, Manoharan V, Sangthongpitag K, Alam J, Poulsen A, Ho SY, Virshup DM, Keller TH. Duraiswamy AJ, et al. Among authors: virshup dm. J Med Chem. 2015 Aug 13;58(15):5889-99. doi: 10.1021/acs.jmedchem.5b00507. Epub 2015 Jul 16. J Med Chem. 2015. PMID: 26110200
169 results