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Hypothesizing that brain reward circuitry genes are genetic antecedents of pain sensitivity and critical diagnostic and pharmacogenomic treatment targets for chronic pain conditions.
Chen AL, Chen TJ, Waite RL, Reinking J, Tung HL, Rhoades P, Downs BW, Braverman E, Braverman D, Kerner M, Blum SH, DiNubile N, Smith D, Oscar-Berman M, Prihoda TJ, Floyd JB, O'Brien D, Liu HH, Blum K. Chen AL, et al. Among authors: blum sh. Med Hypotheses. 2009 Jan;72(1):14-22. doi: 10.1016/j.mehy.2008.07.059. Epub 2008 Oct 31. Med Hypotheses. 2009. PMID: 18951726 Free PMC article. Review.
Manipulation of catechol-O-methyl-transferase (COMT) activity to influence the attenuation of substance seeking behavior, a subtype of Reward Deficiency Syndrome (RDS), is dependent upon gene polymorphisms: a hypothesis.
Blum K, Chen TJ, Meshkin B, Waite RL, Downs BW, Blum SH, Mengucci JF, Arcuri V, Braverman ER, Palomo T. Blum K, et al. Among authors: blum sh. Med Hypotheses. 2007;69(5):1054-60. doi: 10.1016/j.mehy.2006.12.062. Epub 2007 Apr 30. Med Hypotheses. 2007. PMID: 17467918
Activation instead of blocking mesolimbic dopaminergic reward circuitry is a preferred modality in the long term treatment of reward deficiency syndrome (RDS): a commentary.
Blum K, Chen AL, Chen TJ, Braverman ER, Reinking J, Blum SH, Cassel K, Downs BW, Waite RL, Williams L, Prihoda TJ, Kerner MM, Palomo T, Comings DE, Tung H, Rhoades P, Oscar-Berman M. Blum K, et al. Among authors: blum sh. Theor Biol Med Model. 2008 Nov 12;5:24. doi: 10.1186/1742-4682-5-24. Theor Biol Med Model. 2008. PMID: 19014506 Free PMC article. Review.
Nutrigenomic targeting of carbohydrate craving behavior: can we manage obesity and aberrant craving behaviors with neurochemical pathway manipulation by Immunological Compatible Substances (nutrients) using a Genetic Positioning System (GPS) Map?
Downs BW, Chen AL, Chen TJ, Waite RL, Braverman ER, Kerner M, Braverman D, Rhoades P, Prihoda TJ, Palomo T, Oscar-Berman M, Reinking J, Blum SH, DiNubile NA, Liu HH, Blum K. Downs BW, et al. Among authors: blum sh. Med Hypotheses. 2009 Sep;73(3):427-34. doi: 10.1016/j.mehy.2009.02.037. Epub 2009 May 17. Med Hypotheses. 2009. PMID: 19450935 Free PMC article.
Hypothesizing that marijuana smokers are at a significantly lower risk of carcinogenicity relative to tobacco-non-marijuana smokers: evidenced based on statistical reevaluation of current literature.
Chen AL, Chen TJ, Braverman ER, Acuri V, Kemer M, Varshavskiy M, Braverman D, Downs WB, Blum SH, Cassel K, Blum K. Chen AL, et al. Among authors: blum sh. J Psychoactive Drugs. 2008 Sep;40(3):263-72. doi: 10.1080/02791072.2008.10400641. J Psychoactive Drugs. 2008. PMID: 19004418 Review.
Attention-deficit-hyperactivity disorder and reward deficiency syndrome.
Blum K, Chen AL, Braverman ER, Comings DE, Chen TJ, Arcuri V, Blum SH, Downs BW, Waite RL, Notaro A, Lubar J, Williams L, Prihoda TJ, Palomo T, Oscar-Berman M. Blum K, et al. Among authors: blum sh. Neuropsychiatr Dis Treat. 2008 Oct;4(5):893-918. doi: 10.2147/ndt.s2627. Neuropsychiatr Dis Treat. 2008. PMID: 19183781 Free PMC article.
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