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Synthesis, antimalarial activity, and preclinical pharmacology of a novel series of 4'-fluoro and 4'-chloro analogues of amodiaquine. Identification of a suitable "back-up" compound for N-tert-butyl isoquine.
O'Neill PM, Shone AE, Stanford D, Nixon G, Asadollahy E, Park BK, Maggs JL, Roberts P, Stocks PA, Biagini G, Bray PG, Davies J, Berry N, Hall C, Rimmer K, Winstanley PA, Hindley S, Bambal RB, Davis CB, Bates M, Gresham SL, Brigandi RA, Gomez-de-Las-Heras FM, Gargallo DV, Parapini S, Vivas L, Lander H, Taramelli D, Ward SA. O'Neill PM, et al. Among authors: vivas l. J Med Chem. 2009 Apr 9;52(7):1828-44. doi: 10.1021/jm8012757. J Med Chem. 2009. PMID: 19284751 Free article.
In Vivo and In Vitro Activities and ADME-Tox Profile of a Quinolizidine-Modified 4-Aminoquinoline: A Potent Anti-P. falciparum and Anti-P. vivax Blood-Stage Antimalarial.
Basilico N, Parapini S, Sparatore A, Romeo S, Misiano P, Vivas L, Yardley V, Croft SL, Habluetzel A, Lucantoni L, Renia L, Russell B, Suwanarusk R, Nosten F, Dondio G, Bigogno C, Jabes D, Taramelli D. Basilico N, et al. Among authors: vivas l. Molecules. 2017 Dec 1;22(12):2102. doi: 10.3390/molecules22122102. Molecules. 2017. PMID: 29194347 Free PMC article.
Synthesis, in vitro and in vivo antimalarial assessment of sulfide, sulfone and vinyl amide-substituted 1,2,4-trioxanes prepared via thiol-olefin co-oxygenation (TOCO) of allylic alcohols.
Amewu R, Gibbons P, Mukhtar A, Stachulski AV, Ward SA, Hall C, Rimmer K, Davies J, Vivas L, Bacsa J, Mercer AE, Nixon G, Stocks PA, O'Neill PM. Amewu R, et al. Among authors: vivas l. Org Biomol Chem. 2010 May 7;8(9):2068-77. doi: 10.1039/b924319d. Epub 2010 Mar 3. Org Biomol Chem. 2010. PMID: 20401383 Free article.
In vitro anti-malarial activity of N6-modified purine analogs.
Too K, Brown DM, Loakes D, Bongard E, Vivas L. Too K, et al. Among authors: vivas l. Nucleosides Nucleotides Nucleic Acids. 2007;26(6-7):579-83. doi: 10.1080/15257770701490134. Nucleosides Nucleotides Nucleic Acids. 2007. PMID: 18066859
132 results