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Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling.
Britschgi A, Bill A, Brinkhaus H, Rothwell C, Clay I, Duss S, Rebhan M, Raman P, Guy CT, Wetzel K, George E, Popa MO, Lilley S, Choudhury H, Gosling M, Wang L, Fitzgerald S, Borawski J, Baffoe J, Labow M, Gaither LA, Bentires-Alj M. Britschgi A, et al. Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):E1026-34. doi: 10.1073/pnas.1217072110. Epub 2013 Feb 19. Proc Natl Acad Sci U S A. 2013. PMID: 23431153 Free PMC article.
The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα.
Britschgi A, Duss S, Kim S, Couto JP, Brinkhaus H, Koren S, De Silva D, Mertz KD, Kaup D, Varga Z, Voshol H, Vissieres A, Leroy C, Roloff T, Stadler MB, Scheel CH, Miraglia LJ, Orth AP, Bonamy GM, Reddy VA, Bentires-Alj M. Britschgi A, et al. Nature. 2017 Jan 26;541(7638):541-545. doi: 10.1038/nature20829. Epub 2017 Jan 9. Nature. 2017. PMID: 28068668 Free PMC article.
PIK3CA(H1047R) induces multipotency and multi-lineage mammary tumours.
Koren S, Reavie L, Couto JP, De Silva D, Stadler MB, Roloff T, Britschgi A, Eichlisberger T, Kohler H, Aina O, Cardiff RD, Bentires-Alj M. Koren S, et al. Among authors: britschgi a. Nature. 2015 Sep 3;525(7567):114-8. doi: 10.1038/nature14669. Epub 2015 Aug 12. Nature. 2015. PMID: 26266975
A high-throughput drug screen reveals means to differentiate triple-negative breast cancer.
Vulin M, Jehanno C, Sethi A, Correia AL, Obradović MMS, Couto JP, Coissieux MM, Diepenbruck M, Preca BT, Volkmann K, der Maur PA, Schmidt A, Münst S, Sauteur L, Kloc M, Palafox M, Britschgi A, Unterreiner V, Galuba O, Claerr I, Lopez-Romero S, Galli GG, Baeschlin D, Okamoto R, Soysal SD, Mechera R, Weber WP, Radimerski T, Bentires-Alj M. Vulin M, et al. Among authors: britschgi a. Oncogene. 2022 Sep;41(39):4459-4473. doi: 10.1038/s41388-022-02429-0. Epub 2022 Aug 25. Oncogene. 2022. PMID: 36008466 Free PMC article.
The tumor suppressor gene DAPK2 is induced by the myeloid transcription factors PU.1 and C/EBPα during granulocytic differentiation but repressed by PML-RARα in APL.
Humbert M, Federzoni EA, Britschgi A, Schläfli AM, Valk PJ, Kaufmann T, Haferlach T, Behre G, Simon HU, Torbett BE, Fey MF, Tschan MP. Humbert M, et al. Among authors: britschgi a. J Leukoc Biol. 2014 Jan;95(1):83-93. doi: 10.1189/jlb.1112608. Epub 2013 Sep 13. J Leukoc Biol. 2014. PMID: 24038216 Free PMC article.
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