Webb TR - Search Results

1

Activating mutations in ALK provide a therapeutic target in neuroblastoma.

George RE, Sanda T, Hanna M, Fröhling S, Luther W 2nd, Zhang J, Ahn Y, Zhou W, London WB, McGrady P, Xue L, Zozulya S, Gregor VE, Webb TR, Gray NS, Gilliland DG, Diller L, Greulich H, Morris SW, Meyerson M, Look AT. George RE, et al. Among authors: webb tr. Nature. 2008 Oct 16;455(7215):975-8. doi: 10.1038/nature07397. Nature. 2008. PMID: 18923525 Free PMC article.

2

Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy.

Webb TR, Slavish J, George RE, Look AT, Xue L, Jiang Q, Cui X, Rentrop WB, Morris SW. Webb TR, et al. Expert Rev Anticancer Ther. 2009 Mar;9(3):331-56. doi: 10.1586/14737140.9.3.331. Expert Rev Anticancer Ther. 2009. PMID: 19275511 Free PMC article. Review.

3

Design and synthesis of a novel tyrosine kinase inhibitor template.

Jake Slavish P, Jiang Q, Cui X, Morris SW, Webb TR. Jake Slavish P, et al. Among authors: webb tr. Bioorg Med Chem. 2009 May 1;17(9):3308-16. doi: 10.1016/j.bmc.2009.03.046. Epub 2009 Mar 27. Bioorg Med Chem. 2009. PMID: 19362847 Free PMC article.

4

Synthesis of an aryloxy oxo pyrimidinone library that displays ALK-selective inhibition.

Slavish PJ, Price JE, Jiang Q, Cui X, Morris SW, Webb TR. Slavish PJ, et al. Among authors: webb tr. Bioorg Med Chem Lett. 2011 Aug 1;21(15):4592-6. doi: 10.1016/j.bmcl.2011.05.103. Epub 2011 Jun 12. Bioorg Med Chem Lett. 2011. PMID: 21708465

5

Design and synthesis of 5-aryl-pyridone-carboxamides as inhibitors of anaplastic lymphoma kinase.

Li R, Xue L, Zhu T, Jiang Q, Cui X, Yan Z, McGee D, Wang J, Gantla VR, Pickens JC, McGrath D, Chucholowski A, Morris SW, Webb TR. Li R, et al. Among authors: webb tr. J Med Chem. 2006 Feb 9;49(3):1006-15. doi: 10.1021/jm050824x. J Med Chem. 2006. PMID: 16451066

6

Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome.

Shirai CL, White BS, Tripathi M, Tapia R, Ley JN, Ndonwi M, Kim S, Shao J, Carver A, Saez B, Fulton RS, Fronick C, O'Laughlin M, Lagisetti C, Webb TR, Graubert TA, Walter MJ. Shirai CL, et al. Among authors: webb tr. Nat Commun. 2017 Jan 9;8:14060. doi: 10.1038/ncomms14060. Nat Commun. 2017. PMID: 28067246 Free PMC article.

7

Antitumor compounds based on a natural product consensus pharmacophore.

Lagisetti C, Pourpak A, Jiang Q, Cui X, Goronga T, Morris SW, Webb TR. Lagisetti C, et al. Among authors: webb tr. J Med Chem. 2008 Oct 9;51(19):6220-4. doi: 10.1021/jm8006195. Epub 2008 Sep 13. J Med Chem. 2008. PMID: 18788726 Free PMC article.

8

Design, synthesis and initial biological evaluation of a novel pladienolide analog scaffold.

Gundluru MK, Pourpak A, Cui X, Morris SW, Webb TR. Gundluru MK, et al. Among authors: webb tr. Medchemcomm. 2011 Jan 1;2(9):904-908. doi: 10.1039/C1MD00040C. Medchemcomm. 2011. PMID: 21927710 Free PMC article.

9

Synthetic mRNA splicing modulator compounds with in vivo antitumor activity.

Lagisetti C, Pourpak A, Goronga T, Jiang Q, Cui X, Hyle J, Lahti JM, Morris SW, Webb TR. Lagisetti C, et al. Among authors: webb tr. J Med Chem. 2009 Nov 26;52(22):6979-90. doi: 10.1021/jm901215m. J Med Chem. 2009. PMID: 19877647 Free PMC article.

10

The spliceosome is a therapeutic vulnerability in MYC-driven cancer.

Hsu TY, Simon LM, Neill NJ, Marcotte R, Sayad A, Bland CS, Echeverria GV, Sun T, Kurley SJ, Tyagi S, Karlin KL, Dominguez-Vidaña R, Hartman JD, Renwick A, Scorsone K, Bernardi RJ, Skinner SO, Jain A, Orellana M, Lagisetti C, Golding I, Jung SY, Neilson JR, Zhang XH, Cooper TA, Webb TR, Neel BG, Shaw CA, Westbrook TF. Hsu TY, et al. Among authors: webb tr. Nature. 2015 Sep 17;525(7569):384-8. doi: 10.1038/nature14985. Epub 2015 Sep 2. Nature. 2015. PMID: 26331541 Free PMC article.

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