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Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells.
PLoS One. 2008 Sep 26;3(9):e3287. doi: 10.1371/journal.pone.0003287.
PLoS One. 2008.
PMID: 18818766
Free PMC article.
Semaphorin-3B is an angiogenesis inhibitor that is inactivated by furin-like pro-protein convertases.
Varshavsky A, Kessler O, Abramovitch S, Kigel B, Zaffryar S, Akiri G, Neufeld G.
Varshavsky A, et al. Among authors: kigel b.
Cancer Res. 2008 Sep 1;68(17):6922-31. doi: 10.1158/0008-5472.CAN-07-5408.
Cancer Res. 2008.
PMID: 18757406
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Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF and bFGF signaling.
Kigel B, Rabinowicz N, Varshavsky A, Kessler O, Neufeld G.
Kigel B, et al.
Blood. 2011 Oct 13;118(15):4285-96. doi: 10.1182/blood-2011-03-341388. Epub 2011 Aug 10.
Blood. 2011.
PMID: 21832283
Free article.
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Semaphorin-3D and semaphorin-3E inhibit the development of tumors from glioblastoma cells implanted in the cortex of the brain.
Sabag AD, Bode J, Fink D, Kigel B, Kugler W, Neufeld G.
Sabag AD, et al. Among authors: kigel b.
PLoS One. 2012;7(8):e42912. doi: 10.1371/journal.pone.0042912. Epub 2012 Aug 24.
PLoS One. 2012.
PMID: 22936999
Free PMC article.
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Tumour growth inhibition and anti-metastatic activity of a mutated furin-resistant Semaphorin 3E isoform.
Casazza A, Kigel B, Maione F, Capparuccia L, Kessler O, Giraudo E, Mazzone M, Neufeld G, Tamagnone L.
Casazza A, et al. Among authors: kigel b.
EMBO Mol Med. 2012 Mar;4(3):234-50. doi: 10.1002/emmm.201100205. Epub 2012 Jan 13.
EMBO Mol Med. 2012.
PMID: 22247010
Free PMC article.
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A SEMA3E mutant resistant to cleavage by furins (UNCL-SEMA3E) inhibits choroidal neovascularization.
Toledano S, Lu H, Palacio A, Kigel B, Kessler O, Allon G, Barak Y, Neufeld G, Schaal S.
Toledano S, et al. Among authors: kigel b.
Exp Eye Res. 2016 Dec;153:186-194. doi: 10.1016/j.exer.2016.10.004. Epub 2016 Oct 7.
Exp Eye Res. 2016.
PMID: 27725196
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