Theil FP - Search Results

1

Whole body physiologically-based pharmacokinetic models: their use in clinical drug development.

Edginton AN, Theil FP, Schmitt W, Willmann S. Edginton AN, et al. Among authors: theil fp. Expert Opin Drug Metab Toxicol. 2008 Sep;4(9):1143-52. doi: 10.1517/17425255.4.9.1143. Expert Opin Drug Metab Toxicol. 2008. PMID: 18721109 Review.

2

Physiologically based pharmacokinetic models of small molecules and therapeutic antibodies: a mini-review on fundamental concepts and applications.

Ferl GZ, Theil FP, Wong H. Ferl GZ, et al. Among authors: theil fp. Biopharm Drug Dispos. 2016 Mar;37(2):75-92. doi: 10.1002/bdd.1994. Biopharm Drug Dispos. 2016. PMID: 26461173 Review.

3

Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection.

Theil FP, Guentert TW, Haddad S, Poulin P. Theil FP, et al. Toxicol Lett. 2003 Feb 18;138(1-2):29-49. doi: 10.1016/s0378-4274(02)00374-0. Toxicol Lett. 2003. PMID: 12559691 Review.

4

Prediction of pharmacokinetics prior to in vivo studies. II. Generic physiologically based pharmacokinetic models of drug disposition.

Poulin P, Theil FP. Poulin P, et al. Among authors: theil fp. J Pharm Sci. 2002 May;91(5):1358-70. doi: 10.1002/jps.10128. J Pharm Sci. 2002. PMID: 11977112

5

An algorithm for evaluating potential tissue drug distribution in toxicology studies from readily available pharmacokinetic parameters.

Poulin P, Dambach DM, Hartley DH, Ford K, Theil FP, Harstad E, Halladay J, Choo E, Boggs J, Liederer BM, Dean B, Diaz D. Poulin P, et al. Among authors: theil fp. J Pharm Sci. 2013 Oct;102(10):3816-29. doi: 10.1002/jps.23670. Epub 2013 Jul 22. J Pharm Sci. 2013. PMID: 23878104

6

Physiologically based pharmacokinetic (PBPK) modeling of disposition of epiroprim in humans.

Luttringer O, Theil FP, Poulin P, Schmitt-Hoffmann AH, Guentert TW, Lavé T. Luttringer O, et al. Among authors: theil fp. J Pharm Sci. 2003 Oct;92(10):1990-2007. doi: 10.1002/jps.10461. J Pharm Sci. 2003. PMID: 14502539

7

Interplay of dissolution, solubility, and nonsink permeation determines the oral absorption of the Hedgehog pathway inhibitor GDC-0449 in dogs: an investigation using preclinical studies and physiologically based pharmacokinetic modeling.

Wong H, Theil FP, Cui Y, Marsters JC Jr, Khojasteh SC, Vernillet L, La H, Song X, Wang H, Morinello EJ, Deng Y, Hop CE. Wong H, et al. Among authors: theil fp. Drug Metab Dispos. 2010 Jul;38(7):1029-38. doi: 10.1124/dmd.110.032680. Epub 2010 Apr 20. Drug Metab Dispos. 2010. PMID: 20406853

8

A priori prediction of tissue:plasma partition coefficients of drugs to facilitate the use of physiologically-based pharmacokinetic models in drug discovery.

Poulin P, Theil FP. Poulin P, et al. Among authors: theil fp. J Pharm Sci. 2000 Jan;89(1):16-35. doi: 10.1002/(SICI)1520-6017(200001)89:1<16::AID-JPS3>3.0.CO;2-E. J Pharm Sci. 2000. PMID: 10664535

9

A hybrid approach to advancing quantitative prediction of tissue distribution of basic drugs in human.

Poulin P, Ekins S, Theil FP. Poulin P, et al. Among authors: theil fp. Toxicol Appl Pharmacol. 2011 Jan 15;250(2):194-212. doi: 10.1016/j.taap.2010.10.014. Epub 2010 Oct 27. Toxicol Appl Pharmacol. 2011. PMID: 21034759

10

Antitumor activity of targeted and cytotoxic agents in murine subcutaneous tumor models correlates with clinical response.

Wong H, Choo EF, Alicke B, Ding X, La H, McNamara E, Theil FP, Tibbitts J, Friedman LS, Hop CE, Gould SE. Wong H, et al. Among authors: theil fp. Clin Cancer Res. 2012 Jul 15;18(14):3846-55. doi: 10.1158/1078-0432.CCR-12-0738. Epub 2012 May 30. Clin Cancer Res. 2012. PMID: 22648270

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