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Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease.
Jo DG, Arumugam TV, Woo HN, Park JS, Tang SC, Mughal M, Hyun DH, Park JH, Choi YH, Gwon AR, Camandola S, Cheng A, Cai H, Song W, Markesbery WR, Mattson MP. Jo DG, et al. Among authors: mattson mp. Neurobiol Aging. 2010 Jun;31(6):917-25. doi: 10.1016/j.neurobiolaging.2008.07.003. Epub 2008 Aug 8. Neurobiol Aging. 2010. PMID: 18687504 Free PMC article.
Molecular changes in brain aging and Alzheimer's disease are mirrored in experimentally silenced cortical neuron networks.
Gleichmann M, Zhang Y, Wood WH 3rd, Becker KG, Mughal MR, Pazin MJ, van Praag H, Kobilo T, Zonderman AB, Troncoso JC, Markesbery WR, Mattson MP. Gleichmann M, et al. Among authors: mattson mp. Neurobiol Aging. 2012 Jan;33(1):205.e1-18. doi: 10.1016/j.neurobiolaging.2010.08.012. Epub 2010 Oct 13. Neurobiol Aging. 2012. PMID: 20947216 Free PMC article.
Oxidative lipid modification of nicastrin enhances amyloidogenic γ-secretase activity in Alzheimer's disease.
Gwon AR, Park JS, Arumugam TV, Kwon YK, Chan SL, Kim SH, Baik SH, Yang S, Yun YK, Choi Y, Kim S, Tang SC, Hyun DH, Cheng A, Dann CE 3rd, Bernier M, Lee J, Markesbery WR, Mattson MP, Jo DG. Gwon AR, et al. Among authors: mattson mp. Aging Cell. 2012 Aug;11(4):559-68. doi: 10.1111/j.1474-9726.2012.00817.x. Epub 2012 Apr 9. Aging Cell. 2012. PMID: 22404891 Free PMC article.
980 results