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Flexibility between the protease and helicase domains of the dengue virus NS3 protein conferred by the linker region and its functional implications.
Luo D, Wei N, Doan DN, Paradkar PN, Chong Y, Davidson AD, Kotaka M, Lescar J, Vasudevan SG. Luo D, et al. J Biol Chem. 2010 Jun 11;285(24):18817-27. doi: 10.1074/jbc.M109.090936. Epub 2010 Apr 7. J Biol Chem. 2010. PMID: 20375022 Free PMC article.
The structure at 3.15 A of the soluble NS3 protein from DENV4 covalently attached to 18 residues of the NS2B cofactor region (NS2B(18)NS3) revealed an elongated molecule with the protease domain abutting subdomains I and II of the helicase (Luo, D., Xu, T., Hunke, C …
The structure at 3.15 A of the soluble NS3 protein from DENV4 covalently attached to 18 residues of the NS2B cofactor region (NS2B(18)NS3) r …
5,619 results