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Beta-secretase: structure, function, and evolution.
Venugopal C, Demos CM, Rao KS, Pappolla MA, Sambamurti K. Venugopal C, et al. Among authors: sambamurti k. CNS Neurol Disord Drug Targets. 2008 Jun;7(3):278-94. doi: 10.2174/187152708784936626. CNS Neurol Disord Drug Targets. 2008. PMID: 18673212 Free PMC article. Review.
Targets for AD treatment: conflicting messages from γ-secretase inhibitors.
Sambamurti K, Greig NH, Utsuki T, Barnwell EL, Sharma E, Mazell C, Bhat NR, Kindy MS, Lahiri DK, Pappolla MA. Sambamurti K, et al. J Neurochem. 2011 May;117(3):359-74. doi: 10.1111/j.1471-4159.2011.07213.x. Epub 2011 Mar 15. J Neurochem. 2011. PMID: 21320126 Free PMC article.
We have previously proposed that inhibition of gamma-secretase may impair membrane recycling causing neurodegeneration starting at synapses (Sambamurti K., Suram A., Venugopal C., Prakasam A., Zhou Y., Lahiri D. K. and Greig N. H. A partial failure of membran …
We have previously proposed that inhibition of gamma-secretase may impair membrane recycling causing neurodegeneration starting at synapses …
Evidence of a novel mechanism for partial γ-secretase inhibition induced paradoxical increase in secreted amyloid β protein.
Barnwell E, Padmaraju V, Baranello R, Pacheco-Quinto J, Crosson C, Ablonczy Z, Eckman E, Eckman CB, Ramakrishnan V, Greig NH, Pappolla MA, Sambamurti K. Barnwell E, et al. Among authors: sambamurti k. PLoS One. 2014 Mar 21;9(3):e91531. doi: 10.1371/journal.pone.0091531. eCollection 2014. PLoS One. 2014. PMID: 24658363 Free PMC article.
Genotoxicity in Alzheimer's disease: role of amyloid.
Suram A, Venugopal C, Prakasam A, Sambamurti K. Suram A, et al. Among authors: sambamurti k. Curr Alzheimer Res. 2006 Sep;3(4):365-75. doi: 10.2174/156720506778249380. Curr Alzheimer Res. 2006. PMID: 17017867 Review.
115 results