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2-Arylpyrimidines: novel CRF-1 receptor antagonists.
Yoon T, De Lombaert S, Brodbeck R, Gulianello M, Krause JE, Hutchison A, Horvath RF, Ge P, Kehne J, Hoffman D, Chandrasekhar J, Doller D, Hodgetts KJ. Yoon T, et al. Among authors: brodbeck r. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4486-90. doi: 10.1016/j.bmcl.2008.07.063. Epub 2008 Jul 18. Bioorg Med Chem Lett. 2008. PMID: 18672365
Aminopyrazine CB1 receptor inverse agonists.
Wustrow DJ, Maynard GD, Yuan J, Zhao H, Mao J, Guo Q, Kershaw M, Hammer J, Brodbeck RM, Near KE, Zhou D, Beers DS, Chenard BL, Krause JE, Hutchison AJ. Wustrow DJ, et al. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3376-81. doi: 10.1016/j.bmcl.2008.04.022. Epub 2008 Apr 13. Bioorg Med Chem Lett. 2008. PMID: 18448340
Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 1: identification and structure-activity relationships.
Zhao H, Thurkauf A, He X, Hodgetts K, Zhang X, Rachwal S, Kover RX, Hutchison A, Peterson J, Kieltyka A, Brodbeck R, Primus R, Wasley JW. Zhao H, et al. Among authors: brodbeck r. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3105-9. doi: 10.1016/s0960-894x(02)00655-8. Bioorg Med Chem Lett. 2002. PMID: 12372512
Design, synthesis, and discovery of 5-piperazinyl-1,2,6,7-tetrahydro-5H-azepino[3,2,1-hi]indol-4-one derivatives: a novel series of mixed dopamine D2/D4 receptor antagonist.
Zhao H, Zhang X, Hodgetts K, Thurkauf A, Hammer J, Chandrasekhar J, Kieltyka A, Brodbeck R, Rachwal S, Primus R, Manly C. Zhao H, et al. Among authors: brodbeck r. Bioorg Med Chem Lett. 2003 Feb 24;13(4):701-4. doi: 10.1016/s0960-894x(02)01056-9. Bioorg Med Chem Lett. 2003. PMID: 12639562
The design, synthesis and structure-activity relationships of 1-aryl-4-aminoalkylisoquinolines: a novel series of CRF-1 receptor antagonists.
Yoon T, De Lombaert S, Brodbeck R, Gulianello M, Chandrasekhar J, Horvath RF, Ge P, Kershaw MT, Krause JE, Kehne J, Hoffman D, Doller D, Hodgetts KJ. Yoon T, et al. Among authors: brodbeck r. Bioorg Med Chem Lett. 2008 Feb 1;18(3):891-6. doi: 10.1016/j.bmcl.2007.12.050. Epub 2008 Jan 3. Bioorg Med Chem Lett. 2008. PMID: 18180159
Discovery of N-(1-ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98-2): an orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist.
Hodgetts KJ, Ge P, Yoon T, De Lombaert S, Brodbeck R, Gulianello M, Kieltyka A, Horvath RF, Kehne JH, Krause JE, Maynard GD, Hoffman D, Lee Y, Fung L, Doller D. Hodgetts KJ, et al. Among authors: brodbeck r. J Med Chem. 2011 Jun 23;54(12):4187-206. doi: 10.1021/jm200365y. Epub 2011 May 27. J Med Chem. 2011. PMID: 21618986
Molecular characterization of the gerbil C5a receptor and identification of a transmembrane domain V amino acid that is crucial for small molecule antagonist interaction.
Waters SM, Brodbeck RM, Steflik J, Yu J, Baltazar C, Peck AE, Severance D, Zhang LY, Currie K, Chenard BL, Hutchison AJ, Maynard G, Krause JE. Waters SM, et al. J Biol Chem. 2005 Dec 9;280(49):40617-23. doi: 10.1074/jbc.M509245200. Epub 2005 Oct 17. J Biol Chem. 2005. PMID: 16230349 Free article.
58 results