Chiosis G - Search Results

1

Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling.

Ganesh T, Min J, Thepchatri P, Du Y, Li L, Lewis I, Wilson L, Fu H, Chiosis G, Dingledine R, Liotta D, Snyder JP, Sun A. Ganesh T, et al. Among authors: chiosis g. Bioorg Med Chem. 2008 Jul 15;16(14):6903-10. doi: 10.1016/j.bmc.2008.05.047. Epub 2008 May 27. Bioorg Med Chem. 2008. PMID: 18571929 Free PMC article.

2

Development of a purine-scaffold novel class of Hsp90 binders that inhibit the proliferation of cancer cells and induce the degradation of Her2 tyrosine kinase.

Chiosis G, Lucas B, Shtil A, Huezo H, Rosen N. Chiosis G, et al. Bioorg Med Chem. 2002 Nov;10(11):3555-64. doi: 10.1016/s0968-0896(02)00253-5. Bioorg Med Chem. 2002. PMID: 12213470

3

Synthesis of novel fluorescent probes for the molecular chaperone Hsp90.

Llauger-Bufi L, Felts SJ, Huezo H, Rosen N, Chiosis G. Llauger-Bufi L, et al. Among authors: chiosis g. Bioorg Med Chem Lett. 2003 Nov 17;13(22):3975-8. doi: 10.1016/j.bmcl.2003.08.065. Bioorg Med Chem Lett. 2003. PMID: 14592488

4

Targeting wide-range oncogenic transformation via PU24FCl, a specific inhibitor of tumor Hsp90.

Vilenchik M, Solit D, Basso A, Huezo H, Lucas B, He H, Rosen N, Spampinato C, Modrich P, Chiosis G. Vilenchik M, et al. Among authors: chiosis g. Chem Biol. 2004 Jun;11(6):787-97. doi: 10.1016/j.chembiol.2004.04.008. Chem Biol. 2004. PMID: 15217612

5

Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90.

Llauger L, He H, Kim J, Aguirre J, Rosen N, Peters U, Davies P, Chiosis G. Llauger L, et al. Among authors: chiosis g. J Med Chem. 2005 Apr 21;48(8):2892-905. doi: 10.1021/jm049012b. J Med Chem. 2005. PMID: 15828828

6

Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.

He H, Zatorska D, Kim J, Aguirre J, Llauger L, She Y, Wu N, Immormino RM, Gewirth DT, Chiosis G. He H, et al. Among authors: chiosis g. J Med Chem. 2006 Jan 12;49(1):381-90. doi: 10.1021/jm0508078. J Med Chem. 2006. PMID: 16392823

7

New arylthioindoles: potent inhibitors of tubulin polymerization. 2. Structure-activity relationships and molecular modeling studies.

De Martino G, Edler MC, La Regina G, Coluccia A, Barbera MC, Barrow D, Nicholson RI, Chiosis G, Brancale A, Hamel E, Artico M, Silvestri R. De Martino G, et al. Among authors: chiosis g. J Med Chem. 2006 Feb 9;49(3):947-54. doi: 10.1021/jm050809s. J Med Chem. 2006. PMID: 16451061

8

Emerging Hsp90 inhibitors: from discovery to clinic.

Chiosis G, Rodina A, Moulick K. Chiosis G, et al. Anticancer Agents Med Chem. 2006 Jan;6(1):1-8. doi: 10.2174/187152006774755483. Anticancer Agents Med Chem. 2006. PMID: 16475922 Review.

9

Synthesis of Hsp90 dimerization modulators.

Chiosis G, Aguirre J, Nicchitta CV. Chiosis G, et al. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3529-32. doi: 10.1016/j.bmcl.2006.03.092. Epub 2006 Apr 18. Bioorg Med Chem Lett. 2006. PMID: 16621545

10

Synthesis of a red-shifted fluorescence polarization probe for Hsp90.

Moulick K, Clement CC, Aguirre J, Kim J, Kang Y, Felts S, Chiosis G. Moulick K, et al. Among authors: chiosis g. Bioorg Med Chem Lett. 2006 Sep 1;16(17):4515-8. doi: 10.1016/j.bmcl.2006.06.025. Epub 2006 Jun 22. Bioorg Med Chem Lett. 2006. PMID: 16797988

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