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Discovery of a small-molecule HIV-1 integrase inhibitor-binding site.
Al-Mawsawi LQ, Fikkert V, Dayam R, Witvrouw M, Burke TR Jr, Borchers CH, Neamati N. Al-Mawsawi LQ, et al. Among authors: neamati n. Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):10080-5. doi: 10.1073/pnas.0511254103. Epub 2006 Jun 19. Proc Natl Acad Sci U S A. 2006. PMID: 16785440 Free PMC article.
Design of second generation HIV-1 integrase inhibitors.
Deng J, Dayam R, Al-Mawsawi LQ, Neamati N. Deng J, et al. Among authors: neamati n. Curr Pharm Des. 2007;13(2):129-41. doi: 10.2174/138161207779313687. Curr Pharm Des. 2007. PMID: 17269923 Review.
Substituted 2-pyrrolinone inhibitors of HIV-1 integrase.
Dayam R, Al-Mawsawi LQ, Neamati N. Dayam R, et al. Among authors: neamati n. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6155-9. doi: 10.1016/j.bmcl.2007.09.061. Epub 2007 Sep 20. Bioorg Med Chem Lett. 2007. PMID: 17911021
Previously, utilizing a beta-diketoacid pharmacophore as a search query, we identified a substituted 2-pyrrolinone with modest IN inhibitory activity from a database of small-molecules [Dayam, R.; Sanchez, T.; Neamati, N. J. Med. Chem.2005, 48, 8009]. In efforts to …
Previously, utilizing a beta-diketoacid pharmacophore as a search query, we identified a substituted 2-pyrrolinone with modest IN inhibitory …
HIV-1 integrase inhibitors: 2005-2006 update.
Dayam R, Gundla R, Al-Mawsawi LQ, Neamati N. Dayam R, et al. Among authors: neamati n. Med Res Rev. 2008 Jan;28(1):118-54. doi: 10.1002/med.20116. Med Res Rev. 2008. PMID: 17979144 Review.
285 results