Substituted 2-pyrrolinone inhibitors of HIV-1 integrase.
Dayam R, Al-Mawsawi LQ, Neamati N.
Dayam R, et al. Among authors: neamati n.
Bioorg Med Chem Lett. 2007 Nov 15;17(22):6155-9. doi: 10.1016/j.bmcl.2007.09.061. Epub 2007 Sep 20.
Bioorg Med Chem Lett. 2007.
PMID: 17911021
Previously, utilizing a beta-diketoacid pharmacophore as a search query, we identified a substituted 2-pyrrolinone with modest IN inhibitory activity from a database of small-molecules [Dayam, R.; Sanchez, T.; Neamati, N. J. Med. Chem.2005, 48, 8009]. In efforts to …
Previously, utilizing a beta-diketoacid pharmacophore as a search query, we identified a substituted 2-pyrrolinone with modest IN inhibitory …