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Discovery and characterization of QPT-1, the progenitor of a new class of bacterial topoisomerase inhibitors.
Miller AA, Bundy GL, Mott JE, Skepner JE, Boyle TP, Harris DW, Hromockyj AE, Marotti KR, Zurenko GE, Munzner JB, Sweeney MT, Bammert GF, Hamel JC, Ford CW, Zhong WZ, Graber DR, Martin GE, Han F, Dolak LA, Seest EP, Ruble JC, Kamilar GM, Palmer JR, Banitt LS, Hurd AR, Barbachyn MR. Miller AA, et al. Among authors: hurd ar. Antimicrob Agents Chemother. 2008 Aug;52(8):2806-12. doi: 10.1128/AAC.00247-08. Epub 2008 Jun 2. Antimicrob Agents Chemother. 2008. PMID: 18519725 Free PMC article.
Discovery of LYC-55716: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ) Agonist for Use in Treating Cancer.
Aicher TD, Van Huis CA, Hurd AR, Skalitzky DJ, Taylor CB, Beleh OM, Glick G, Toogood PL, Yang B, Zheng T, Huo C, Gao J, Qiao C, Tian X, Zhang J, Demock K, Hao LY, Lesch CA, Morgan RW, Moisan J, Wang Y, Scatina J, Paulos CM, Zou W, Carter LL, Hu X. Aicher TD, et al. Among authors: hurd ar. J Med Chem. 2021 Sep 23;64(18):13410-13428. doi: 10.1021/acs.jmedchem.1c00731. Epub 2021 Sep 9. J Med Chem. 2021. PMID: 34499493
Synthetic RORγ agonists regulate multiple pathways to enhance antitumor immunity.
Hu X, Liu X, Moisan J, Wang Y, Lesch CA, Spooner C, Morgan RW, Zawidzka EM, Mertz D, Bousley D, Majchrzak K, Kryczek I, Taylor C, Van Huis C, Skalitzky D, Hurd A, Aicher TD, Toogood PL, Glick GD, Paulos CM, Zou W, Carter LL. Hu X, et al. Oncoimmunology. 2016 Nov 4;5(12):e1254854. doi: 10.1080/2162402X.2016.1254854. eCollection 2016. Oncoimmunology. 2016. PMID: 28123897 Free PMC article.
Synthesis of (+)-casuarine.
Denmark SE, Hurd AR. Denmark SE, et al. Among authors: hurd ar. J Org Chem. 2000 May 19;65(10):2875-86. doi: 10.1021/jo991680v. J Org Chem. 2000. PMID: 10814173
Synthesis of (+)-casuarine.
Denmark SE, Hurd AR. Denmark SE, et al. Among authors: hurd ar. Org Lett. 1999 Oct 21;1(8):1311-4. doi: 10.1021/ol9909886. Org Lett. 1999. PMID: 10825980
11 results