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Design, synthesis and evaluation of potent thymidylate synthase X inhibitors.
Esra Onen F, Boum Y, Jacquement C, Spanedda MV, Jaber N, Scherman D, Myllykallio H, Herscovici J. Esra Onen F, et al. Among authors: myllykallio h. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3628-31. doi: 10.1016/j.bmcl.2008.04.080. Epub 2008 May 6. Bioorg Med Chem Lett. 2008. PMID: 18513963
Catalytic mechanism and structure of viral flavin-dependent thymidylate synthase ThyX.
Graziani S, Bernauer J, Skouloubris S, Graille M, Zhou CZ, Marchand C, Decottignies P, van Tilbeurgh H, Myllykallio H, Liebl U. Graziani S, et al. Among authors: myllykallio h. J Biol Chem. 2006 Aug 18;281(33):24048-57. doi: 10.1074/jbc.M600745200. Epub 2006 May 17. J Biol Chem. 2006. PMID: 16707489 Free article.
Mechanistic and structural basis for inhibition of thymidylate synthase ThyX.
Basta T, Boum Y, Briffotaux J, Becker HF, Lamarre-Jouenne I, Lambry JC, Skouloubris S, Liebl U, Graille M, van Tilbeurgh H, Myllykallio H. Basta T, et al. Among authors: myllykallio h. Open Biol. 2012 Oct;2(10):120120. doi: 10.1098/rsob.120120. Open Biol. 2012. PMID: 23155486 Free PMC article.
Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase.
Salo-Ahen OM, Tochowicz A, Pozzi C, Cardinale D, Ferrari S, Boum Y, Mangani S, Stroud RM, Saxena P, Myllykallio H, Costi MP, Ponterini G, Wade RC. Salo-Ahen OM, et al. Among authors: myllykallio h. J Med Chem. 2015 Apr 23;58(8):3572-81. doi: 10.1021/acs.jmedchem.5b00137. Epub 2015 Apr 1. J Med Chem. 2015. PMID: 25798950 Free PMC article.
Predictive modeling targets thymidylate synthase ThyX in Mycobacterium tuberculosis.
Djaout K, Singh V, Boum Y, Katawera V, Becker HF, Bush NG, Hearnshaw SJ, Pritchard JE, Bourbon P, Madrid PB, Maxwell A, Mizrahi V, Myllykallio H, Ekins S. Djaout K, et al. Among authors: myllykallio h. Sci Rep. 2016 Jun 10;6:27792. doi: 10.1038/srep27792. Sci Rep. 2016. PMID: 27283217 Free PMC article.
73 results