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Structure-based design, synthesis, and biological evaluation of conformationally restricted novel 2-alkylthio-6-[1-(2,6-difluorophenyl)alkyl]-3,4-dihydro-5-alkylpyrimidin-4(3H)-ones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Mai A, Sbardella G, Artico M, Ragno R, Massa S, Novellino E, Greco G, Lavecchia A, Musiu C, La Colla M, Murgioni C, La Colla P, Loddo R. Mai A, et al. Among authors: loddo r. J Med Chem. 2001 Aug 2;44(16):2544-54. doi: 10.1021/jm010853h. J Med Chem. 2001. PMID: 11472208
DABOs as candidates to prevent mucosal HIV transmission.
Pani A, Musiu C, Loi AG, Mai A, Loddo R, La Colla P, Marongiu ME. Pani A, et al. Among authors: loddo r. Antivir Chem Chemother. 2001;12 Suppl 1:51-9. Antivir Chem Chemother. 2001. PMID: 11594689
A combined in silico/in vitro approach unveils common molecular requirements for efficient BVDV RdRp binding of linear aromatic N-polycyclic systems.
Carta A, Briguglio I, Piras S, Corona P, Ibba R, Laurini E, Fermeglia M, Pricl S, Desideri N, Atzori EM, La Colla P, Collu G, Delogu I, Loddo R. Carta A, et al. Among authors: loddo r. Eur J Med Chem. 2016 Jul 19;117:321-34. doi: 10.1016/j.ejmech.2016.03.080. Epub 2016 Apr 8. Eur J Med Chem. 2016. PMID: 27161176
101 results