Paine MF - Search Results

1

The influence of CYP3A5 genotype on dexamethasone induction of CYP3A activity in African Americans.

Roberts PJ, Rollins KD, Kashuba AD, Paine MF, Nelsen AC, Williams EE, Moran C, Lamba JK, Schuetz EG, Hawke RL. Roberts PJ, et al. Among authors: paine mf. Drug Metab Dispos. 2008 Aug;36(8):1465-9. doi: 10.1124/dmd.107.020065. Epub 2008 May 19. Drug Metab Dispos. 2008. PMID: 18490434 Free PMC article.

2

Two major grapefruit juice components differ in intestinal CYP3A4 inhibition kinetic and binding properties.

Paine MF, Criss AB, Watkins PB. Paine MF, et al. Drug Metab Dispos. 2004 Oct;32(10):1146-53. doi: 10.1124/dmd.104.000547. Epub 2004 Jul 21. Drug Metab Dispos. 2004. PMID: 15269184

3

Do men and women differ in proximal small intestinal CYP3A or P-glycoprotein expression?

Paine MF, Ludington SS, Chen ML, Stewart PW, Huang SM, Watkins PB. Paine MF, et al. Drug Metab Dispos. 2005 Mar;33(3):426-33. doi: 10.1124/dmd.104.002469. Epub 2004 Dec 17. Drug Metab Dispos. 2005. PMID: 15608139

4

Variation in oral clearance of saquinavir is predicted by CYP3A5*1 genotype but not by enterocyte content of cytochrome P450 3A5.

Mouly SJ, Matheny C, Paine MF, Smith G, Lamba J, Lamba V, Pusek SN, Schuetz EG, Stewart PW, Watkins PB. Mouly SJ, et al. Among authors: paine mf. Clin Pharmacol Ther. 2005 Dec;78(6):605-18. doi: 10.1016/j.clpt.2005.08.014. Clin Pharmacol Ther. 2005. PMID: 16338276 Clinical Trial.

5

The human intestinal cytochrome P450 "pie".

Paine MF, Hart HL, Ludington SS, Haining RL, Rettie AE, Zeldin DC. Paine MF, et al. Drug Metab Dispos. 2006 May;34(5):880-6. doi: 10.1124/dmd.105.008672. Epub 2006 Feb 7. Drug Metab Dispos. 2006. PMID: 16467132 Free PMC article.

6

CYP4F enzymes are the major enzymes in human liver microsomes that catalyze the O-demethylation of the antiparasitic prodrug DB289 [2,5-bis(4-amidinophenyl)furan-bis-O-methylamidoxime].

Wang MZ, Saulter JY, Usuki E, Cheung YL, Hall M, Bridges AS, Loewen G, Parkinson OT, Stephens CE, Allen JL, Zeldin DC, Boykin DW, Tidwell RR, Parkinson A, Paine MF, Hall JE. Wang MZ, et al. Among authors: paine mf. Drug Metab Dispos. 2006 Dec;34(12):1985-94. doi: 10.1124/dmd.106.010587. Epub 2006 Sep 22. Drug Metab Dispos. 2006. PMID: 16997912 Free PMC article.

7

Clinical relevance of the small intestine as an organ of drug elimination: drug-fruit juice interactions.

Paine MF, Oberlies NH. Paine MF, et al. Expert Opin Drug Metab Toxicol. 2007 Feb;3(1):67-80. doi: 10.1517/17425255.3.1.67. Expert Opin Drug Metab Toxicol. 2007. PMID: 17269895 Review.

8

Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine.

Wang MZ, Wu JQ, Bridges AS, Zeldin DC, Kornbluth S, Tidwell RR, Hall JE, Paine MF. Wang MZ, et al. Among authors: paine mf. Drug Metab Dispos. 2007 Nov;35(11):2067-75. doi: 10.1124/dmd.107.016428. Epub 2007 Aug 20. Drug Metab Dispos. 2007. PMID: 17709372 Free PMC article.

9

The influence of CYP3A5 expression on the extent of hepatic CYP3A inhibition is substrate-dependent: an in vitro-in vivo evaluation.

Isoherranen N, Ludington SR, Givens RC, Lamba JK, Pusek SN, Dees EC, Blough DK, Iwanaga K, Hawke RL, Schuetz EG, Watkins PB, Thummel KE, Paine MF. Isoherranen N, et al. Among authors: paine mf. Drug Metab Dispos. 2008 Jan;36(1):146-54. doi: 10.1124/dmd.107.018382. Epub 2007 Oct 22. Drug Metab Dispos. 2008. PMID: 17954524

10

Identification of a cranberry juice product that inhibits enteric CYP3A-mediated first-pass metabolism in humans.

Ngo N, Yan Z, Graf TN, Carrizosa DR, Kashuba AD, Dees EC, Oberlies NH, Paine MF. Ngo N, et al. Among authors: paine mf. Drug Metab Dispos. 2009 Mar;37(3):514-22. doi: 10.1124/dmd.108.024968. Epub 2008 Dec 29. Drug Metab Dispos. 2009. PMID: 19114462 Free PMC article.

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