Dou D - Search Results

1

Inhibition of serine proteases by a new class of cyclosulfamide-based carbamylating agents.

Yang Q, Li Y, Dou D, Gan X, Mohan S, Groutas CS, Stevenson LE, Lai Z, Alliston KR, Zhong J, Williams TD, Groutas WC. Yang Q, et al. Among authors: dou d. Arch Biochem Biophys. 2008 Jul 15;475(2):115-20. doi: 10.1016/j.abb.2008.04.020. Epub 2008 Apr 22. Arch Biochem Biophys. 2008. PMID: 18457652 Free PMC article.

2

Inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1 dioxide-based sulfonamides.

Li Y, Yang Q, Dou D, Alliston KR, Groutas WC. Li Y, et al. Among authors: dou d. Bioorg Med Chem. 2008 Jan 15;16(2):692-8. doi: 10.1016/j.bmc.2007.10.041. Epub 2007 Oct 18. Bioorg Med Chem. 2008. PMID: 17976994 Free PMC article.

3

X-ray snapshot of the mechanism of inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives.

Huang W, Yamamoto Y, Li Y, Dou D, Alliston KR, Hanzlik RP, Williams TD, Groutas WC. Huang W, et al. Among authors: dou d. J Med Chem. 2008 Apr 10;51(7):2003-8. doi: 10.1021/jm700966p. Epub 2008 Mar 5. J Med Chem. 2008. PMID: 18318470 Free PMC article.

4

Mechanism-based inhibitors of serine proteases with high selectivity through optimization of S' subsite binding.

Li Y, Dou D, He G, Lushington GH, Groutas WC. Li Y, et al. Among authors: dou d. Bioorg Med Chem. 2009 May 15;17(10):3536-42. doi: 10.1016/j.bmc.2009.04.011. Epub 2009 Apr 12. Bioorg Med Chem. 2009. PMID: 19394830 Free PMC article.

5

Utilization of the 1,2,3,5-thiatriazolidin-3-one 1,1-dioxide scaffold in the design of potential inhibitors of human neutrophil proteinase 3.

Dou D, He G, Li Y, Lai Z, Wei L, Alliston KR, Lushington GH, Eichhorn DM, Groutas WC. Dou D, et al. Bioorg Med Chem. 2010 Feb;18(3):1093-102. doi: 10.1016/j.bmc.2009.12.057. Epub 2009 Dec 29. Bioorg Med Chem. 2010. PMID: 20061159 Free PMC article.

6

Inhibitors of human neutrophil elastase based on a highly functionalized N-amino-4-imidazolidinone scaffold.

He G, Dou D, Wei L, Alliston KR, Groutas WC. He G, et al. Among authors: dou d. Eur J Med Chem. 2010 Sep;45(9):4280-7. doi: 10.1016/j.ejmech.2010.06.028. Epub 2010 Jun 30. Eur J Med Chem. 2010. PMID: 20638756 Free PMC article.

7

Neutrophil elastase inhibitors.

Groutas WC, Dou D, Alliston KR. Groutas WC, et al. Among authors: dou d. Expert Opin Ther Pat. 2011 Mar;21(3):339-54. doi: 10.1517/13543776.2011.551115. Epub 2011 Jan 16. Expert Opin Ther Pat. 2011. PMID: 21235378 Free PMC article. Review.

8

Design and synthesis of inhibitors of noroviruses by scaffold hopping.

Dou D, Mandadapu SR, Alliston KR, Kim Y, Chang KO, Groutas WC. Dou D, et al. Bioorg Med Chem. 2011 Oct 1;19(19):5749-55. doi: 10.1016/j.bmc.2011.08.032. Epub 2011 Aug 22. Bioorg Med Chem. 2011. PMID: 21893416 Free PMC article.

9

Cyclosulfamide-based derivatives as inhibitors of noroviruses.

Dou D, Mandadapu SR, Alliston KR, Kim Y, Chang KO, Groutas WC. Dou D, et al. Eur J Med Chem. 2012 Jan;47(1):59-64. doi: 10.1016/j.ejmech.2011.10.019. Epub 2011 Oct 20. Eur J Med Chem. 2012. PMID: 22063754 Free PMC article.

10

Effects of structure on inhibitory activity in a series of mechanism-based inhibitors of human neutrophil elastase.

Dou D, He G, Kuang R, Fu Q, Venkataraman R, Groutas WC. Dou D, et al. Bioorg Med Chem. 2010 Sep 15;18(18):6646-50. doi: 10.1016/j.bmc.2010.07.071. Epub 2010 Aug 5. Bioorg Med Chem. 2010. PMID: 20728366 Free PMC article.

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