Eggler AL - Search Results

1

Molecular mechanisms of natural products in chemoprevention: induction of cytoprotective enzymes by Nrf2.

Eggler AL, Gay KA, Mesecar AD. Eggler AL, et al. Mol Nutr Food Res. 2008 Jun;52 Suppl 1:S84-94. doi: 10.1002/mnfr.200700249. Mol Nutr Food Res. 2008. PMID: 18435489 Review.

2

Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2.

Eggler AL, Liu G, Pezzuto JM, van Breemen RB, Mesecar AD. Eggler AL, et al. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10070-5. doi: 10.1073/pnas.0502402102. Epub 2005 Jul 8. Proc Natl Acad Sci U S A. 2005. PMID: 16006525 Free PMC article.

3

Identification of the highly reactive cysteine 151 in the chemopreventive agent-sensor Keap1 protein is method-dependent.

Eggler AL, Luo Y, van Breemen RB, Mesecar AD. Eggler AL, et al. Chem Res Toxicol. 2007 Dec;20(12):1878-84. doi: 10.1021/tx700217c. Epub 2007 Oct 13. Chem Res Toxicol. 2007. PMID: 17935299

4

Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1.

Eggler AL, Small E, Hannink M, Mesecar AD. Eggler AL, et al. Biochem J. 2009 Jul 29;422(1):171-80. doi: 10.1042/BJ20090471. Biochem J. 2009. PMID: 19489739 Free PMC article.

5

Screening for natural chemoprevention agents that modify human Keap1.

Hu C, Nikolic D, Eggler AL, Mesecar AD, van Breemen RB. Hu C, et al. Among authors: eggler al. Anal Biochem. 2012 Feb 1;421(1):108-14. doi: 10.1016/j.ab.2011.10.028. Epub 2011 Oct 22. Anal Biochem. 2012. PMID: 22074792 Free PMC article.

6

Development of an efficient E. coli expression and purification system for a catalytically active, human Cullin3-RINGBox1 protein complex and elucidation of its quaternary structure with Keap1.

Small E, Eggler A, Mesecar AD. Small E, et al. Biochem Biophys Res Commun. 2010 Oct 1;400(4):471-5. doi: 10.1016/j.bbrc.2010.08.062. Epub 2010 Aug 22. Biochem Biophys Res Commun. 2010. PMID: 20735986 Free PMC article.

7

Xanthohumol isolated from Humulus lupulus Inhibits menadione-induced DNA damage through induction of quinone reductase.

Dietz BM, Kang YH, Liu G, Eggler AL, Yao P, Chadwick LR, Pauli GF, Farnsworth NR, Mesecar AD, van Breemen RB, Bolton JL. Dietz BM, et al. Among authors: eggler al. Chem Res Toxicol. 2005 Aug;18(8):1296-305. doi: 10.1021/tx050058x. Chem Res Toxicol. 2005. PMID: 16097803 Free PMC article.

8

Screening method for the discovery of potential cancer chemoprevention agents based on mass spectrometric detection of alkylated Keap1.

Liu G, Eggler AL, Dietz BM, Mesecar AD, Bolton JL, Pezzuto JM, van Breemen RB. Liu G, et al. Among authors: eggler al. Anal Chem. 2005 Oct 1;77(19):6407-14. doi: 10.1021/ac050892r. Anal Chem. 2005. PMID: 16194107

9

Sites of alkylation of human Keap1 by natural chemoprevention agents.

Luo Y, Eggler AL, Liu D, Liu G, Mesecar AD, van Breemen RB. Luo Y, et al. Among authors: eggler al. J Am Soc Mass Spectrom. 2007 Dec;18(12):2226-32. doi: 10.1016/j.jasms.2007.09.015. Epub 2007 Oct 2. J Am Soc Mass Spectrom. 2007. PMID: 17980616 Free PMC article.

10

Modification of keap1 cysteine residues by sulforaphane.

Hu C, Eggler AL, Mesecar AD, van Breemen RB. Hu C, et al. Among authors: eggler al. Chem Res Toxicol. 2011 Apr 18;24(4):515-21. doi: 10.1021/tx100389r. Epub 2011 Mar 10. Chem Res Toxicol. 2011. PMID: 21391649 Free PMC article.

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