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The size and/or configuration of the cycloalkane D' ring in pentacyclic progesterone derivatives are crucial for their high-affinity binding to a protein in addition to progesterone receptor in rat uterine cytosol.
Smirnov AN, Pokrovskaya EV, Kogteva GS, Shevchenko VP, Levina IS, Kulikova LE, Kamernitzky AV. Smirnov AN, et al. Among authors: pokrovskaya ev. Steroids. 2000 Mar;65(3):163-70. doi: 10.1016/s0039-128x(99)00100-2. Steroids. 2000. PMID: 10699596