Paine SW - Search Results

1

Prediction of the pharmacokinetics of atorvastatin, cerivastatin, and indomethacin using kinetic models applied to isolated rat hepatocytes.

Paine SW, Parker AJ, Gardiner P, Webborn PJ, Riley RJ. Paine SW, et al. Drug Metab Dispos. 2008 Jul;36(7):1365-74. doi: 10.1124/dmd.107.019455. Epub 2008 Apr 21. Drug Metab Dispos. 2008. PMID: 18426955

2

Prediction of human renal clearance from preclinical species for a diverse set of drugs that exhibit both active secretion and net reabsorption.

Paine SW, Ménochet K, Denton R, McGinnity DF, Riley RJ. Paine SW, et al. Drug Metab Dispos. 2011 Jun;39(6):1008-13. doi: 10.1124/dmd.110.037267. Epub 2011 Feb 28. Drug Metab Dispos. 2011. PMID: 21357702

3

The impact of hepatic uptake on the pharmacokinetics of organic anions.

Gardiner P, Paine SW. Gardiner P, et al. Among authors: paine sw. Drug Metab Dispos. 2011 Oct;39(10):1930-8. doi: 10.1124/dmd.111.039842. Epub 2011 Jul 21. Drug Metab Dispos. 2011. PMID: 21778353

4

From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis.

Springthorpe B, Bailey A, Barton P, Birkinshaw TN, Bonnert RV, Brown RC, Chapman D, Dixon J, Guile SD, Humphries RG, Hunt SF, Ince F, Ingall AH, Kirk IP, Leeson PD, Leff P, Lewis RJ, Martin BP, McGinnity DF, Mortimore MP, Paine SW, Pairaudeau G, Patel A, Rigby AJ, Riley RJ, Teobald BJ, Tomlinson W, Webborn PJ, Willis PA. Springthorpe B, et al. Among authors: paine sw. Bioorg Med Chem Lett. 2007 Nov 1;17(21):6013-8. doi: 10.1016/j.bmcl.2007.07.057. Epub 2007 Aug 19. Bioorg Med Chem Lett. 2007. PMID: 17827008

5

Zwitterionic CRTh2 antagonists.

Luker T, Bonnert R, Paine SW, Schmidt J, Sargent C, Cook AR, Cook A, Gardiner P, Hill S, Weyman-Jones C, Patel A, Thom S, Thorne P. Luker T, et al. Among authors: paine sw. J Med Chem. 2011 Mar 24;54(6):1779-88. doi: 10.1021/jm1014549. Epub 2011 Feb 28. J Med Chem. 2011. PMID: 21355602

6

Characteristics of AZD9708, a novel, selective β2-adrenoceptor agonist with rapid onset and long duration of action.

Nicholls DJ, Jordan S, Cadogan E, Lawson M, Austin RP, Paine SW, Gardiner P, Bonnert R, Connolly S, Young A. Nicholls DJ, et al. Among authors: paine sw. Pulm Pharmacol Ther. 2012 Aug;25(4):293-302. doi: 10.1016/j.pupt.2012.05.008. Epub 2012 May 29. Pulm Pharmacol Ther. 2012. PMID: 22659538

7

Species differences in biliary clearance and possible relevance of hepatic uptake and efflux transporters involvement.

Grime K, Paine SW. Grime K, et al. Among authors: paine sw. Drug Metab Dispos. 2013 Feb;41(2):372-8. doi: 10.1124/dmd.112.049312. Epub 2012 Nov 8. Drug Metab Dispos. 2013. PMID: 23139379

8

In silico prediction of acyl glucuronide reactivity.

Potter T, Lewis R, Luker T, Bonnert R, Bernstein MA, Birkinshaw TN, Thom S, Wenlock M, Paine S. Potter T, et al. J Comput Aided Mol Des. 2011 Nov;25(11):997-1005. doi: 10.1007/s10822-011-9479-0. Epub 2011 Oct 26. J Comput Aided Mol Des. 2011. PMID: 22042375

9

In silico human and rat Vss quantitative structure-activity relationship models.

Gleeson MP, Waters NJ, Paine SW, Davis AM. Gleeson MP, et al. Among authors: paine sw. J Med Chem. 2006 Mar 23;49(6):1953-63. doi: 10.1021/jm0510070. J Med Chem. 2006. PMID: 16539383

10

A rapid computational filter for predicting the rate of human renal clearance.

Paine SW, Barton P, Bird J, Denton R, Menochet K, Smith A, Tomkinson NP, Chohan KK. Paine SW, et al. J Mol Graph Model. 2010 Dec;29(4):529-37. doi: 10.1016/j.jmgm.2010.10.003. Epub 2010 Oct 20. J Mol Graph Model. 2010. PMID: 21075652

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