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PPARdelta regulates multiple proinflammatory pathways to suppress atherosclerosis.
Barish GD, Atkins AR, Downes M, Olson P, Chong LW, Nelson M, Zou Y, Hwang H, Kang H, Curtiss L, Evans RM, Lee CH. Barish GD, et al. Among authors: kang h. Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4271-6. doi: 10.1073/pnas.0711875105. Epub 2008 Mar 12. Proc Natl Acad Sci U S A. 2008. PMID: 18337509 Free PMC article.
PPARdelta is a very low-density lipoprotein sensor in macrophages.
Chawla A, Lee CH, Barak Y, He W, Rosenfeld J, Liao D, Han J, Kang H, Evans RM. Chawla A, et al. Among authors: kang h. Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1268-73. doi: 10.1073/pnas.0337331100. Epub 2003 Jan 22. Proc Natl Acad Sci U S A. 2003. PMID: 12540828 Free PMC article.
PPARdelta regulates glucose metabolism and insulin sensitivity.
Lee CH, Olson P, Hevener A, Mehl I, Chong LW, Olefsky JM, Gonzalez FJ, Ham J, Kang H, Peters JM, Evans RM. Lee CH, et al. Among authors: kang h. Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3444-9. doi: 10.1073/pnas.0511253103. Epub 2006 Feb 21. Proc Natl Acad Sci U S A. 2006. PMID: 16492734 Free PMC article.
Regulation of muscle fiber type and running endurance by PPARdelta.
Wang YX, Zhang CL, Yu RT, Cho HK, Nelson MC, Bayuga-Ocampo CR, Ham J, Kang H, Evans RM. Wang YX, et al. Among authors: kang h. PLoS Biol. 2004 Oct;2(10):e294. doi: 10.1371/journal.pbio.0020294. Epub 2004 Aug 24. PLoS Biol. 2004. PMID: 15328533 Free PMC article.
AMPK and PPARdelta agonists are exercise mimetics.
Narkar VA, Downes M, Yu RT, Embler E, Wang YX, Banayo E, Mihaylova MM, Nelson MC, Zou Y, Juguilon H, Kang H, Shaw RJ, Evans RM. Narkar VA, et al. Among authors: kang h. Cell. 2008 Aug 8;134(3):405-15. doi: 10.1016/j.cell.2008.06.051. Epub 2008 Jul 31. Cell. 2008. PMID: 18674809 Free PMC article.
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