Withers SG - Search Results

1

A new generation of specific Trypanosoma cruzi trans-sialidase inhibitors.

Buchini S, Buschiazzo A, Withers SG. Buchini S, et al. Among authors: withers sg. Angew Chem Int Ed Engl. 2008;47(14):2700-3. doi: 10.1002/anie.200705435. Angew Chem Int Ed Engl. 2008. PMID: 18300214 No abstract available.

2

beta-Mannosynthase: Synthesis of beta-Mannosides with a Mutant beta-Mannosidase We thank the Protein Engineering Network of Centres of Excellence of Canada and the Natural Sciences and Engineering Research Council of Canada for support. D.L.Z. thanks the Izaak Walton Killam Foundation for a fellowship.

Nashiru O, Zechel DL, Stoll D, Mohammadzadeh T, Warren RA, Withers SG. Nashiru O, et al. Among authors: withers sg. Angew Chem Int Ed Engl. 2001 Jan 19;40(2):417-420. Angew Chem Int Ed Engl. 2001. PMID: 11180343 No abstract available.

3

Thioglycoligases: mutant glycosidases for thioglycoside synthesis.

Jahn M, Marles J, Warren RA, Withers SG. Jahn M, et al. Among authors: withers sg. Angew Chem Int Ed Engl. 2003 Jan 20;42(3):352-4. doi: 10.1002/anie.200390114. Angew Chem Int Ed Engl. 2003. PMID: 12548697 No abstract available.

4

Trypanosoma cruzi trans-sialidase operates through a covalent sialyl-enzyme intermediate: tyrosine is the catalytic nucleophile.

Watts AG, Damager I, Amaya ML, Buschiazzo A, Alzari P, Frasch AC, Withers SG. Watts AG, et al. Among authors: withers sg. J Am Chem Soc. 2003 Jun 25;125(25):7532-3. doi: 10.1021/ja0344967. J Am Chem Soc. 2003. PMID: 12812490

5

Structural insights into the catalytic mechanism of Trypanosoma cruzi trans-sialidase.

Amaya MF, Watts AG, Damager I, Wehenkel A, Nguyen T, Buschiazzo A, Paris G, Frasch AC, Withers SG, Alzari PM. Amaya MF, et al. Among authors: withers sg. Structure. 2004 May;12(5):775-84. doi: 10.1016/j.str.2004.02.036. Structure. 2004. PMID: 15130470 Free article.

6

Structural and kinetic analysis of two covalent sialosyl-enzyme intermediates on Trypanosoma rangeli sialidase.

Watts AG, Oppezzo P, Withers SG, Alzari PM, Buschiazzo A. Watts AG, et al. Among authors: withers sg. J Biol Chem. 2006 Feb 17;281(7):4149-55. doi: 10.1074/jbc.M510677200. Epub 2005 Nov 18. J Biol Chem. 2006. PMID: 16298994 Free article.

7

Glycosylation of a neoglycoprotein by using glycosynthase and thioglycoligase approaches: the generation of a thioglycoprotein.

Müllegger J, Chen HM, Warren RA, Withers SG. Müllegger J, et al. Among authors: withers sg. Angew Chem Int Ed Engl. 2006 Apr 10;45(16):2585-8. doi: 10.1002/anie.200503900. Angew Chem Int Ed Engl. 2006. PMID: 16528765 No abstract available.

8

High-throughput screening methodology for the directed evolution of glycosyltransferases.

Aharoni A, Thieme K, Chiu CP, Buchini S, Lairson LL, Chen H, Strynadka NC, Wakarchuk WW, Withers SG. Aharoni A, et al. Among authors: withers sg. Nat Methods. 2006 Aug;3(8):609-14. doi: 10.1038/nmeth899. Nat Methods. 2006. PMID: 16862135

9

Family 4 glycosidases carry out efficient hydrolysis of thioglycosides by an alpha,beta-elimination mechanism.

Yip VL, Withers SG. Yip VL, et al. Among authors: withers sg. Angew Chem Int Ed Engl. 2006 Sep 18;45(37):6179-82. doi: 10.1002/anie.200601421. Angew Chem Int Ed Engl. 2006. PMID: 16917793 No abstract available.

10

The structural basis of glycosidase inhibition by five-membered iminocyclitols: the clan a glycoside hydrolase endoglycoceramidase as a model system.

Caines ME, Hancock SM, Tarling CA, Wrodnigg TM, Stick RV, Stütz AE, Vasella A, Withers SG, Strynadka NC. Caines ME, et al. Among authors: withers sg. Angew Chem Int Ed Engl. 2007;46(24):4474-6. doi: 10.1002/anie.200700268. Angew Chem Int Ed Engl. 2007. PMID: 17487923 No abstract available.

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