Tyndall JD - Search Results

1

Peptides and small molecules targeting the plasminogen activation system: towards prophylactic anti-metastasis drugs for breast cancer.

Tyndall JD, Kelso MJ, Clingan P, Ranson M. Tyndall JD, et al. Recent Pat Anticancer Drug Discov. 2008 Jan;3(1):1-13. doi: 10.2174/157489208783478711. Recent Pat Anticancer Drug Discov. 2008. PMID: 18289119 Review.

2

Conformationally homogeneous cyclic tetrapeptides: useful new three-dimensional scaffolds.

Glenn MP, Kelso MJ, Tyndall JD, Fairlie DP. Glenn MP, et al. Among authors: tyndall jd. J Am Chem Soc. 2003 Jan 22;125(3):640-1. doi: 10.1021/ja029205t. J Am Chem Soc. 2003. PMID: 12526657

3

Synthesis and preliminary evaluation of amiloride analogs as inhibitors of the urokinase-type plasminogen activator (uPA).

Matthews H, Ranson M, Tyndall JD, Kelso MJ. Matthews H, et al. Among authors: tyndall jd. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6760-6. doi: 10.1016/j.bmcl.2011.09.044. Epub 2011 Sep 18. Bioorg Med Chem Lett. 2011. PMID: 21978672

4

An amiloride derivative is active against the F₁F_o-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis.

Hards K, Cheung CY, Waller N, Adolph C, Keighley L, Tee ZS, Harold LK, Menorca A, Bujaroski RS, Buckley BJ, Tyndall JDA, McNeil MB, Rhee KY, Opel-Reading HK, Krause K, Preiss L, Langer JD, Meier T, Hasenoehrl EJ, Berney M, Kelso MJ, Cook GM. Hards K, et al. Among authors: tyndall jda. Commun Biol. 2022 Feb 24;5(1):166. doi: 10.1038/s42003-022-03110-8. Commun Biol. 2022. PMID: 35210534 Free PMC article.

5

A dual-targeting succinate dehydrogenase and F₁F_o-ATP synthase inhibitor rapidly sterilizes replicating and non-replicating Mycobacterium tuberculosis.

Adolph C, Cheung CY, McNeil MB, Jowsey WJ, Williams ZC, Hards K, Harold LK, Aboelela A, Bujaroski RS, Buckley BJ, Tyndall JDA, Li Z, Langer JD, Preiss L, Meier T, Steyn AJC, Rhee KY, Berney M, Kelso MJ, Cook GM. Adolph C, et al. Among authors: tyndall jda. Cell Chem Biol. 2024 Apr 18;31(4):683-698.e7. doi: 10.1016/j.chembiol.2023.12.002. Epub 2023 Dec 26. Cell Chem Biol. 2024. PMID: 38151019

6

Optimization of peptide-based inhibitors targeting the HtrA serine protease in Chlamydia: Design, synthesis and biological evaluation of pyridone-based and N-Capping group-modified analogues.

Hwang J, Strange N, Phillips MJA, Krause AL, Heywood A, Gamble AB, Huston WM, Tyndall JDA. Hwang J, et al. Eur J Med Chem. 2021 Nov 15;224:113692. doi: 10.1016/j.ejmech.2021.113692. Epub 2021 Jul 7. Eur J Med Chem. 2021. PMID: 34265463

7

GPCR agonists and antagonists in the clinic.

Tyndall JD, Sandilya R. Tyndall JD, et al. Med Chem. 2005 Jul;1(4):405-21. doi: 10.2174/1573406054368675. Med Chem. 2005. PMID: 16789897 Review.

8

Chlamydia Serine Protease Inhibitor, targeting HtrA, as a New Treatment for Koala Chlamydia infection.

Lawrence A, Fraser T, Gillett A, Tyndall JD, Timms P, Polkinghorne A, Huston WM. Lawrence A, et al. Among authors: tyndall jd. Sci Rep. 2016 Aug 17;6:31466. doi: 10.1038/srep31466. Sci Rep. 2016. PMID: 27530689 Free PMC article.

9

Proteases and protease inhibitors in infectious diseases.

Agbowuro AA, Huston WM, Gamble AB, Tyndall JDA. Agbowuro AA, et al. Med Res Rev. 2018 Jul;38(4):1295-1331. doi: 10.1002/med.21475. Epub 2017 Nov 17. Med Res Rev. 2018. PMID: 29149530 Review.

10

Design, synthesis and biological evaluation of P2-modified proline analogues targeting the HtrA serine protease in Chlamydia.

Hwang J, Strange N, Mazraani R, Phillips MJ, Gamble AB, Huston WM, Tyndall JDA. Hwang J, et al. Among authors: tyndall jda. Eur J Med Chem. 2022 Feb 15;230:114064. doi: 10.1016/j.ejmech.2021.114064. Epub 2021 Dec 31. Eur J Med Chem. 2022. PMID: 35007862

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