Skaggs BJ - Search Results

1

IkappaB kinase beta inhibition induces cell death in Imatinib-resistant and T315I Dasatinib-resistant BCR-ABL+ cells.

Duncan EA, Goetz CA, Stein SJ, Mayo KJ, Skaggs BJ, Ziegelbauer K, Sawyers CL, Baldwin AS. Duncan EA, et al. Among authors: skaggs bj. Mol Cancer Ther. 2008 Feb;7(2):391-7. doi: 10.1158/1535-7163.MCT-07-0305. Epub 2008 Feb 1. Mol Cancer Ther. 2008. PMID: 18245668

2

Sequential ABL kinase inhibitor therapy selects for compound drug-resistant BCR-ABL mutations with altered oncogenic potency.

Shah NP, Skaggs BJ, Branford S, Hughes TP, Nicoll JM, Paquette RL, Sawyers CL. Shah NP, et al. Among authors: skaggs bj. J Clin Invest. 2007 Sep;117(9):2562-9. doi: 10.1172/JCI30890. J Clin Invest. 2007. PMID: 17710227 Free PMC article.

3

Comparative analysis of two clinically active BCR-ABL kinase inhibitors reveals the role of conformation-specific binding in resistance.

Burgess MR, Skaggs BJ, Shah NP, Lee FY, Sawyers CL. Burgess MR, et al. Among authors: skaggs bj. Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3395-400. doi: 10.1073/pnas.0409770102. Epub 2005 Feb 10. Proc Natl Acad Sci U S A. 2005. PMID: 15705718 Free PMC article.

4

Fitness conferred by BCR-ABL kinase domain mutations determines the risk of pre-existing resistance in chronic myeloid leukemia.

Leder K, Foo J, Skaggs B, Gorre M, Sawyers CL, Michor F. Leder K, et al. PLoS One. 2011;6(11):e27682. doi: 10.1371/journal.pone.0027682. Epub 2011 Nov 28. PLoS One. 2011. PMID: 22140458 Free PMC article.

5

Phosphorylation of the ATP-binding loop directs oncogenicity of drug-resistant BCR-ABL mutants.

Skaggs BJ, Gorre ME, Ryvkin A, Burgess MR, Xie Y, Han Y, Komisopoulou E, Brown LM, Loo JA, Landaw EM, Sawyers CL, Graeber TG. Skaggs BJ, et al. Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19466-71. doi: 10.1073/pnas.0609239103. Epub 2006 Dec 12. Proc Natl Acad Sci U S A. 2006. PMID: 17164333 Free PMC article.

6

MAGI-2 scaffold protein is critical for kidney barrier function.

Balbas MD, Burgess MR, Murali R, Wongvipat J, Skaggs BJ, Mundel P, Weins A, Sawyers CL. Balbas MD, et al. Among authors: skaggs bj. Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14876-81. doi: 10.1073/pnas.1417297111. Epub 2014 Sep 30. Proc Natl Acad Sci U S A. 2014. PMID: 25271328 Free PMC article.

7

Global phosphoproteomics reveals crosstalk between Bcr-Abl and negative feedback mechanisms controlling Src signaling.

Rubbi L, Titz B, Brown L, Galvan E, Komisopoulou E, Chen SS, Low T, Tahmasian M, Skaggs B, Müschen M, Pellegrini M, Graeber TG. Rubbi L, et al. Sci Signal. 2011 Mar 29;4(166):ra18. doi: 10.1126/scisignal.2001314. Sci Signal. 2011. PMID: 21447799 Free PMC article.

8

Maximal entropy inference of oncogenicity from phosphorylation signaling.

Graeber TG, Heath JR, Skaggs BJ, Phelps ME, Remacle F, Levine RD. Graeber TG, et al. Among authors: skaggs bj. Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):6112-7. doi: 10.1073/pnas.1001149107. Epub 2010 Mar 11. Proc Natl Acad Sci U S A. 2010. PMID: 20224037 Free PMC article.

9

Laquinimod delays and suppresses nephritis in lupus-prone mice and affects both myeloid and lymphoid immune cells.

Lourenço EV, Wong M, Hahn BH, Palma-Diaz MF, Skaggs BJ. Lourenço EV, et al. Among authors: skaggs bj. Arthritis Rheumatol. 2014 Mar;66(3):674-85. doi: 10.1002/art.38259. Arthritis Rheumatol. 2014. PMID: 24574228

10

CD8+ Tregs in lupus, autoimmunity, and beyond.

Dinesh RK, Skaggs BJ, La Cava A, Hahn BH, Singh RP. Dinesh RK, et al. Among authors: skaggs bj. Autoimmun Rev. 2010 Jun;9(8):560-8. doi: 10.1016/j.autrev.2010.03.006. Epub 2010 Apr 10. Autoimmun Rev. 2010. PMID: 20385256 Free PMC article. Review.

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