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Biotransformation of 3-amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878), a novel 5-hydroxytryptamine (5-HT)1A agonist/5-HT3 antagonist, in human hepatic cytochrome P450 enzymes.
Drug Metab Dispos. 2008 May;36(5):831-40. doi: 10.1124/dmd.107.018168. Epub 2008 Jan 31.
Drug Metab Dispos. 2008.
PMID: 18238859
Pharmacological properties of 3-amino-5,6,7,8-tetrahydro-2-[4-[4-(quinolin-2-yl)piperazin-1-yl]butyl]quinazolin-4(3H)-one (TZB-30878), a novel therapeutic agent for diarrhea-predominant irritable bowel syndrome (IBS) and its effects on an experimental IBS model.
Tamaoki S, Yamauchi Y, Nakano Y, Sakano S, Asagarasu A, Sato M.
Tamaoki S, et al. Among authors: asagarasu a.
J Pharmacol Exp Ther. 2007 Sep;322(3):1315-23. doi: 10.1124/jpet.107.123729. Epub 2007 May 31.
J Pharmacol Exp Ther. 2007.
PMID: 17540858
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Discovery of a novel 5-HT(3) antagonist/5-HT(1A) agonist 3-amino-5,6,7,8-tetrahydro-2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}quinazolin-4(3H)-one (TZB-30878) as an orally bioavailable agent for irritable bowel syndrome.
Asagarasu A, Matsui T, Hayashi H, Tamaoki S, Yamauchi Y, Minato K, Sato M.
Asagarasu A, et al.
J Med Chem. 2010 Nov 11;53(21):7549-63. doi: 10.1021/jm1002292.
J Med Chem. 2010.
PMID: 20931963
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Design and synthesis of piperazinylpyridine derivatives as novel 5-HT1A agonists/5-HT3 antagonists for the treatment of irritable bowel syndrome (IBS).
Asagarasu A, Matsui T, Hayashi H, Tamaoki S, Yamauchi Y, Sato M.
Asagarasu A, et al.
Chem Pharm Bull (Tokyo). 2009 Jan;57(1):34-42. doi: 10.1248/cpb.57.34.
Chem Pharm Bull (Tokyo). 2009.
PMID: 19122313
Free article.
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Syntheses of HIV-protease inhibitors having a peptide moiety which binds to GP120.
Asagarasu A, Uchiyama T, Achiwa K.
Asagarasu A, et al.
Chem Pharm Bull (Tokyo). 1998 Apr;46(4):697-703. doi: 10.1248/cpb.46.697.
Chem Pharm Bull (Tokyo). 1998.
PMID: 9579045
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Synthesis of dipeptide-type human immunodeficiency virus (HIV) protease inhibitors with a binding unit to gp120.
Asagarasu A, Takayanagi N, Achiwa K.
Asagarasu A, et al.
Chem Pharm Bull (Tokyo). 1998 May;46(5):867-70. doi: 10.1248/cpb.46.867.
Chem Pharm Bull (Tokyo). 1998.
PMID: 9621421
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