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The oral Ca/calmodulin-dependent kinase II inhibitor RA608 improves contractile function and prevents arrhythmias in heart failure.
Mustroph J, Drzymalski M, Baier M, Pabel S, Biedermann A, Memmel B, Durczok M, Neef S, Sag CM, Floerchinger B, Rupprecht L, Schmid C, Zausig Y, Bégis G, Briand V, Ozoux ML, Tamarelle D, Ballet V, Janiak P, Beauverger P, Maier LS, Wagner S. Mustroph J, et al. Among authors: tamarelle d. ESC Heart Fail. 2020 Oct;7(5):2871-2883. doi: 10.1002/ehf2.12895. Epub 2020 Jul 20. ESC Heart Fail. 2020. PMID: 32691522 Free PMC article.
Reversion of cardiac dysfunction by a novel orally available calcium/calmodulin-dependent protein kinase II inhibitor, RA306, in a genetic model of dilated cardiomyopathy.
Beauverger P, Ozoux ML, Bégis G, Glénat V, Briand V, Philippo MC, Daveu C, Tavares G, Roy S, Corbier A, Briand P, Dorchies O, Bauchet AL, Nicolai E, Duclos O, Tamarelle D, Pruniaux MP, Muslin AJ, Janiak P. Beauverger P, et al. Among authors: tamarelle d. Cardiovasc Res. 2020 Feb 1;116(2):329-338. doi: 10.1093/cvr/cvz097. Cardiovasc Res. 2020. PMID: 31038167