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Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series.
Lachance N, Gareau Y, Guiral S, Huang Z, Isabel E, Leclerc JP, Léger S, Martins E, Nadeau C, Oballa RM, Ouellet SG, Powell DA, Ramtohul YK, Tranmer GK, Trinh T, Wang H, Zhang L. Lachance N, et al. Among authors: ouellet sg. Bioorg Med Chem Lett. 2012 Jan 15;22(2):980-4. doi: 10.1016/j.bmcl.2011.12.002. Epub 2011 Dec 8. Bioorg Med Chem Lett. 2012. PMID: 22209206
Discovery of MK-1439, an orally bioavailable non-nucleoside reverse transcriptase inhibitor potent against a wide range of resistant mutant HIV viruses.
Côté B, Burch JD, Asante-Appiah E, Bayly C, Bédard L, Blouin M, Campeau LC, Cauchon E, Chan M, Chefson A, Coulombe N, Cromlish W, Debnath S, Deschênes D, Dupont-Gaudet K, Falgueyret JP, Forget R, Gagné S, Gauvreau D, Girardin M, Guiral S, Langlois E, Li CS, Nguyen N, Papp R, Plamondon S, Roy A, Roy S, Seliniotakis R, St-Onge M, Ouellet S, Tawa P, Truchon JF, Vacca J, Wrona M, Yan Y, Ducharme Y. Côté B, et al. Bioorg Med Chem Lett. 2014 Feb 1;24(3):917-22. doi: 10.1016/j.bmcl.2013.12.070. Epub 2013 Dec 24. Bioorg Med Chem Lett. 2014. PMID: 24412110
Amphoteric Character of 2-Vinyloxiranes: Synthetic Equivalents of beta,gamma-Unsaturated Aldehydes and a Vinylogous Enolate We thank Professor Batey and his group for providing the allyl and crotyltrifluoroborates. This work was supported by the National Science and Engineering Research Council (NSERC) and the University of Toronto. S.G.O. thanks NSERC for a post-graduate scholarship.
Lautens M, Ouellet SG, Raeppel S. Lautens M, et al. Among authors: ouellet sg. Angew Chem Int Ed Engl. 2000 Nov 17;39(22):4079-4082. doi: 10.1002/1521-3773(20001117)39:22<4079::aid-anie4079>3.0.co;2-w. Angew Chem Int Ed Engl. 2000. PMID: 11093211 No abstract available.