Botta M - Search Results

1

A multidisciplinary approach for the identification of novel HIV-1 non-nucleoside reverse transcriptase inhibitors: S-DABOCs and DAVPs.

Radi M, Falciani C, Contemori L, Petricci E, Maga G, Samuele A, Zanoli S, Terrazas M, Castria M, Togninelli A, Esté JA, Clotet-Codina I, Armand-Ugón M, Botta M. Radi M, et al. Among authors: botta m. ChemMedChem. 2008 Apr;3(4):573-93. doi: 10.1002/cmdc.200700198. ChemMedChem. 2008. PMID: 18081133

2

Parallel solution-phase and microwave-assisted synthesis of new S-DABO derivatives endowed with subnanomolar anti-HIV-1 activity.

Manetti F, Esté JA, Clotet-Codina I, Armand-Ugón M, Maga G, Crespan E, Cancio R, Mugnaini C, Bernardini C, Togninelli A, Carmi C, Alongi M, Petricci E, Massa S, Corelli F, Botta M. Manetti F, et al. Among authors: botta m. J Med Chem. 2005 Dec 15;48(25):8000-8. doi: 10.1021/jm050744t. J Med Chem. 2005. PMID: 16335924

3

Synthesis and biological investigation of S-aryl-S-DABO derivatives as HIV-1 inhibitors.

Mugnaini C, Manetti F, Esté JA, Clotet-Codina I, Maga G, Cancio R, Botta M, Corelli F. Mugnaini C, et al. Among authors: botta m. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3541-4. doi: 10.1016/j.bmcl.2006.03.080. Epub 2006 Apr 18. Bioorg Med Chem Lett. 2006. PMID: 16621553

4

A versatile route to C-6 arylmethyl-functionalized S-DABO and related analogues.

Radi M, Contemori L, Castagnolo D, Spinosa R, Esté JA, Massa S, Botta M. Radi M, et al. Among authors: botta m. Org Lett. 2007 Aug 2;9(16):3157-60. doi: 10.1021/ol071225i. Epub 2007 Jul 11. Org Lett. 2007. PMID: 17625879

5

Dihydro-alkylthio-benzyl-oxopyrimidines as inhibitors of reverse transcriptase: synthesis and rationalization of the biological data on both wild-type enzyme and relevant clinical mutants.

Mugnaini C, Alongi M, Togninelli A, Gevariya H, Brizzi A, Manetti F, Bernardini C, Angeli L, Tafi A, Bellucci L, Corelli F, Massa S, Maga G, Samuele A, Facchini M, Clotet-Codina I, Armand-Ugón M, Esté JA, Botta M. Mugnaini C, et al. Among authors: botta m. J Med Chem. 2007 Dec 27;50(26):6580-95. doi: 10.1021/jm0708230. Epub 2007 Dec 6. J Med Chem. 2007. PMID: 18052319

6

Towards novel S-DABOC inhibitors: synthesis, biological investigation, and molecular modeling studies.

Radi M, Angeli L, Franchi L, Contemori L, Maga G, Samuele A, Zanoli S, Armand-Ugon M, Gonzalez E, Llano A, Esté JA, Botta M. Radi M, et al. Among authors: botta m. Bioorg Med Chem Lett. 2008 Nov 1;18(21):5777-80. doi: 10.1016/j.bmcl.2008.09.070. Epub 2008 Sep 23. Bioorg Med Chem Lett. 2008. PMID: 18842407

7

Discovery of chiral cyclopropyl dihydro-alkylthio-benzyl-oxopyrimidine (S-DABO) derivatives as potent HIV-1 reverse transcriptase inhibitors with high activity against clinically relevant mutants.

Radi M, Maga G, Alongi M, Angeli L, Samuele A, Zanoli S, Bellucci L, Tafi A, Casaluce G, Giorgi G, Armand-Ugon M, Gonzalez E, Esté JA, Baltzinger M, Bec G, Dumas P, Ennifar E, Botta M. Radi M, et al. Among authors: botta m. J Med Chem. 2009 Feb 12;52(3):840-51. doi: 10.1021/jm801330n. J Med Chem. 2009. PMID: 19140683

8

Design and synthesis of thiadiazoles and thiazoles targeting the Bcr-Abl T315I mutant: from docking false positives to ATP-noncompetitive inhibitors.

Radi M, Crespan E, Falchi F, Bernardo V, Zanoli S, Manetti F, Schenone S, Maga G, Botta M. Radi M, et al. Among authors: botta m. ChemMedChem. 2010 Aug 2;5(8):1226-31. doi: 10.1002/cmdc.201000066. ChemMedChem. 2010. PMID: 20509136 No abstract available.

9

A versatile and practical synthesis toward the development of novel HIV-1 integrase inhibitors.

Rinaldi M, Tintori C, Franchi L, Vignaroli G, Innitzer A, Massa S, Esté JA, Gonzalo E, Christ F, Debyser Z, Botta M. Rinaldi M, et al. Among authors: botta m. ChemMedChem. 2011 Feb 7;6(2):343-52. doi: 10.1002/cmdc.201000510. Epub 2011 Jan 18. ChemMedChem. 2011. PMID: 21246739

10

Toward the discovery of novel anti-HIV drugs. Second-generation inhibitors of the cellular ATPase DDX3 with improved anti-HIV activity: synthesis, structure-activity relationship analysis, cytotoxicity studies, and target validation.

Maga G, Falchi F, Radi M, Botta L, Casaluce G, Bernardini M, Irannejad H, Manetti F, Garbelli A, Samuele A, Zanoli S, Esté JA, Gonzalez E, Zucca E, Paolucci S, Baldanti F, De Rijck J, Debyser Z, Botta M. Maga G, et al. Among authors: botta m, botta l. ChemMedChem. 2011 Aug 1;6(8):1371-89. doi: 10.1002/cmdc.201100166. Epub 2011 Jun 22. ChemMedChem. 2011. PMID: 21698775

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