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Design of new potent and selective secretory phospholipase A2 inhibitors. Part 5: synthesis and biological activity of 1-alkyl-4-[4,5-dihydro-1,2,4-[4H]-oxadiazol-5-one-3-ylmethylbenz-4'-yl(oyl)] piperazines.
Boukli L, Touaibia M, Meddad-Belhabich N, Djimdé A, Park CH, Kim JJ, Yoon JH, Lamouri A, Heymans F. Boukli L, et al. Bioorg Med Chem. 2008 Feb 1;16(3):1242-53. doi: 10.1016/j.bmc.2007.10.077. Epub 2007 Nov 13. Bioorg Med Chem. 2008. PMID: 17993277
Inhibition of secretory phospholipase A2. 1-design, synthesis and structure-activity relationship studies starting from 4-tetradecyloxybenzamidine to obtain specific inhibitors of group II sPLA2s.
Assogba L, Ahamada-Himidi A, Habich NM, Aoun D, Boukli L, Massicot F, Mounier CM, Huet J, Lamouri A, Ombetta JE, Godfroid JJ, Dong CZ, Heymans F. Assogba L, et al. Among authors: boukli l. Eur J Med Chem. 2005 Sep;40(9):850-61. doi: 10.1016/j.ejmech.2005.03.027. Eur J Med Chem. 2005. PMID: 16084626