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The tumor gene survivin is highly expressed in adult renal tubular cells: implications for a pathophysiological role in the kidney.
Lechler P, Wu X, Bernhardt W, Campean V, Gastiger S, Hackenbeck T, Klanke B, Weidemann A, Warnecke C, Amann K, Engehausen D, Willam C, Eckardt KU, Rödel F, Wiesener MS. Lechler P, et al. Among authors: klanke b. Am J Pathol. 2007 Nov;171(5):1483-98. doi: 10.2353/ajpath.2007.070132. Am J Pathol. 2007. PMID: 17982126 Free PMC article.
HIF activation protects from acute kidney injury.
Weidemann A, Bernhardt WM, Klanke B, Daniel C, Buchholz B, Câmpean V, Amann K, Warnecke C, Wiesener MS, Eckardt KU, Willam C. Weidemann A, et al. Among authors: klanke b. J Am Soc Nephrol. 2008 Mar;19(3):486-94. doi: 10.1681/ASN.2007040419. Epub 2008 Feb 6. J Am Soc Nephrol. 2008. PMID: 18256363 Free PMC article.
The GTPase RAB20 is a HIF target with mitochondrial localization mediating apoptosis in hypoxia.
Hackenbeck T, Huber R, Schietke R, Knaup KX, Monti J, Wu X, Klanke B, Frey B, Gaipl U, Wullich B, Ferbus D, Goubin G, Warnecke C, Eckardt KU, Wiesener MS. Hackenbeck T, et al. Among authors: klanke b. Biochim Biophys Acta. 2011 Jan;1813(1):1-13. doi: 10.1016/j.bbamcr.2010.10.019. Epub 2010 Nov 5. Biochim Biophys Acta. 2011. PMID: 21056597 Free article.
Renal tubular HIF-2α expression requires VHL inactivation and causes fibrosis and cysts.
Schietke RE, Hackenbeck T, Tran M, Günther R, Klanke B, Warnecke CL, Knaup KX, Shukla D, Rosenberger C, Koesters R, Bachmann S, Betz P, Schley G, Schödel J, Willam C, Winkler T, Amann K, Eckardt KU, Maxwell P, Wiesener MS. Schietke RE, et al. Among authors: klanke b. PLoS One. 2012;7(1):e31034. doi: 10.1371/journal.pone.0031034. Epub 2012 Jan 27. PLoS One. 2012. PMID: 22299048 Free PMC article.
Kidney injury is independent of endothelial HIF-1α.
Kalucka J, Schley G, Georgescu A, Klanke B, Rössler S, Baumgartl J, Velden J, Amann K, Willam C, Johnson RS, Eckardt KU, Weidemann A. Kalucka J, et al. Among authors: klanke b. J Mol Med (Berl). 2015 Aug;93(8):891-904. doi: 10.1007/s00109-015-1264-4. Epub 2015 Mar 11. J Mol Med (Berl). 2015. PMID: 25754172 Free PMC article.
40 results