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Effect of rapid human N-acetyltransferase 2 haplotype on DNA damage and mutagenesis induced by 2-amino-3-methylimidazo-[4,5-f]quinoline (IQ) and 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline (MeIQx).
Metry KJ, Neale JR, Doll MA, Howarth AL, States JC, McGregor WG, Pierce WM Jr, Hein DW. Metry KJ, et al. Among authors: neale jr. Mutat Res. 2010 Feb 3;684(1-2):66-73. doi: 10.1016/j.mrfmmm.2009.12.001. Epub 2009 Dec 11. Mutat Res. 2010. PMID: 20004212 Free PMC article.
2-Amino-3,8-dimethylimidazo-[4,5-f]quinoxaline-induced DNA adduct formation and mutagenesis in DNA repair-deficient Chinese hamster ovary cells expressing human cytochrome P4501A1 and rapid or slow acetylator N-acetyltransferase 2.
Bendaly J, Zhao S, Neale JR, Metry KJ, Doll MA, States JC, Pierce WM Jr, Hein DW. Bendaly J, et al. Among authors: neale jr. Cancer Epidemiol Biomarkers Prev. 2007 Jul;16(7):1503-9. doi: 10.1158/1055-9965.EPI-07-0305. Cancer Epidemiol Biomarkers Prev. 2007. PMID: 17627018 Free PMC article.
Effect of N-acetyltransferase 2 polymorphism on tumor target tissue DNA adduct levels in rapid and slow acetylator congenic rats administered 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine or 2-amino-3,8-dimethylimidazo-[4,5-f]quinoxaline.
Metry KJ, Neale JR, Bendaly J, Smith NB, Pierce WM Jr, Hein DW. Metry KJ, et al. Among authors: neale jr. Drug Metab Dispos. 2009 Nov;37(11):2123-6. doi: 10.1124/dmd.109.029512. Epub 2009 Aug 10. Drug Metab Dispos. 2009. PMID: 19666988 Free PMC article.
N-acetyltransferase (Nat) 1 and 2 expression in Nat2 knockout mice.
Loehle JA, Cornish V, Wakefield L, Doll MA, Neale JR, Zang Y, Sim E, Hein DW. Loehle JA, et al. Among authors: neale jr. J Pharmacol Exp Ther. 2006 Nov;319(2):724-8. doi: 10.1124/jpet.106.108662. Epub 2006 Jul 20. J Pharmacol Exp Ther. 2006. PMID: 16857729 Free article.
29 results