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Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity.
Rudolph J, Esler WP, O'connor S, Coish PD, Wickens PL, Brands M, Bierer DE, Bloomquist BT, Bondar G, Chen L, Chuang CY, Claus TH, Fathi Z, Fu W, Khire UR, Kristie JA, Liu XG, Lowe DB, McClure AC, Michels M, Ortiz AA, Ramsden PD, Schoenleber RW, Shelekhin TE, Vakalopoulos A, Tang W, Wang L, Yi L, Gardell SJ, Livingston JN, Sweet LJ, Bullock WH. Rudolph J, et al. Among authors: tang w. J Med Chem. 2007 Oct 18;50(21):5202-16. doi: 10.1021/jm070071+. Epub 2007 Sep 21. J Med Chem. 2007. PMID: 17887659
DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure.
Yan M, Gao J, Lan M, Wang Q, Cao Y, Zheng Y, Yang Y, Li W, Yu X, Huang X, Dou L, Liu B, Liu J, Cheng H, Ouyang K, Xu K, Sun S, Liu J, Tang W, Zhang X, Man Y, Sun L, Cai J, He Q, Tang F, Li J, Shen T. Yan M, et al. Among authors: tang w. Signal Transduct Target Ther. 2024 May 24;9(1):127. doi: 10.1038/s41392-024-01831-2. Signal Transduct Target Ther. 2024. PMID: 38782919
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