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Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity.
J Med Chem. 2007 Oct 18;50(21):5202-16. doi: 10.1021/jm070071+. Epub 2007 Sep 21.
J Med Chem. 2007.
PMID: 17887659
Substituted indanylacetic acids as PPAR-alpha-gamma activators.
Lowe DB, Bifulco N, Bullock WH, Claus T, Coish P, Dai M, Dela Cruz FE, Dickson D, Fan D, Hoover-Litty H, Li T, Ma X, Mannelly G, Monahan MK, Muegge I, O'Connor S, Rodriguez M, Shelekhin T, Stolle A, Sweet L, Wang M, Wang Y, Zhang C, Zhang HJ, Zhang M, Zhao K, Zhao Q, Zhu J, Zhu L, Tsutsumi M.
Lowe DB, et al.
Bioorg Med Chem Lett. 2006 Jan 15;16(2):297-301. doi: 10.1016/j.bmcl.2005.10.008. Epub 2005 Nov 3.
Bioorg Med Chem Lett. 2006.
PMID: 16275080
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Indanylacetic acids as PPAR-delta activator insulin sensitizers.
Wickens P, Zhang C, Ma X, Zhao Q, Amatruda J, Bullock W, Burns M, Cantin LD, Chuang CY, Claus T, Dai M, Dela Cruz F, Dickson D, Ehrgott FJ, Fan D, Heald S, Hentemann M, Iwuagwu CI, Johnson JS, Kumarasinghe E, Ladner D, Lavoie R, Liang S, Livingston JN, Lowe D, Magnuson S, Mannelly G, Mugge I, Ogutu H, Pleasic-Williams S, Schoenleber RW, Shapiro J, Shelekhin T, Sweet L, Town C, Tsutsumi M.
Wickens P, et al.
Bioorg Med Chem Lett. 2007 Aug 1;17(15):4369-73. doi: 10.1016/j.bmcl.2007.03.057. Epub 2007 Mar 23.
Bioorg Med Chem Lett. 2007.
PMID: 17601734
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Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors.
Lin J, Lu W, Caravella JA, Campbell AM, Diebold RB, Ericsson A, Fritzen E, Gustafson GR, Lancia DR Jr, Shelekhin T, Wang Z, Castro J, Clarke A, Gotur D, Josephine HR, Katz M, Diep H, Kershaw M, Yao L, Kauffman G, Hubbs SE, Luke GP, Toms AV, Wang L, Bair KW, Barr KJ, Dinsmore C, Walker D, Ashwell S.
Lin J, et al.
J Med Chem. 2019 Jul 25;62(14):6575-6596. doi: 10.1021/acs.jmedchem.9b00362. Epub 2019 Jul 8.
J Med Chem. 2019.
PMID: 31199148
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Design and evaluation of nitrosylated alpha-adrenergic receptor antagonists as potential agents for the treatment of impotence.
de Tejada IS, Garvey DS, Schroeder JD, Shelekhin T, Letts LG, Fernández A, Cuevas B, Gabancho S, Martínez V, Angulo J, Trocha M, Marek P, Cuevas P, Tam SW.
de Tejada IS, et al.
J Pharmacol Exp Ther. 1999 Jul;290(1):121-8.
J Pharmacol Exp Ther. 1999.
PMID: 10381767
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