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Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity.
Rudolph J, Esler WP, O'connor S, Coish PD, Wickens PL, Brands M, Bierer DE, Bloomquist BT, Bondar G, Chen L, Chuang CY, Claus TH, Fathi Z, Fu W, Khire UR, Kristie JA, Liu XG, Lowe DB, McClure AC, Michels M, Ortiz AA, Ramsden PD, Schoenleber RW, Shelekhin TE, Vakalopoulos A, Tang W, Wang L, Yi L, Gardell SJ, Livingston JN, Sweet LJ, Bullock WH. Rudolph J, et al. Among authors: fathi z. J Med Chem. 2007 Oct 18;50(21):5202-16. doi: 10.1021/jm070071+. Epub 2007 Sep 21. J Med Chem. 2007. PMID: 17887659
Optimization of imidazole amide derivatives as cannabinoid-1 receptor antagonists for the treatment of obesity.
Smith RA, Fathi Z, Achebe F, Akuche C, Brown SE, Choi S, Fan J, Jenkins S, Kluender HC, Konkar A, Lavoie R, Mays R, Natoli J, O'Connor SJ, Ortiz AA, Su N, Taing C, Tomlinson S, Tritto T, Wang G, Wirtz SN, Wong W, Yang XF, Ying S, Zhang Z. Smith RA, et al. Among authors: fathi z. Bioorg Med Chem Lett. 2007 May 15;17(10):2706-11. doi: 10.1016/j.bmcl.2007.03.011. Epub 2007 Mar 12. Bioorg Med Chem Lett. 2007. PMID: 17383180
Identification of selective neuropeptide Y2 peptide agonists.
DeCarr LB, Buckholz TM, Coish PD, Fathi Z, Fisk SE, Mays MR, O'Connor SJ, Lumb KJ. DeCarr LB, et al. Among authors: fathi z. Bioorg Med Chem Lett. 2007 Jan 15;17(2):538-41. doi: 10.1016/j.bmcl.2006.10.007. Epub 2006 Oct 7. Bioorg Med Chem Lett. 2007. PMID: 17055726
Constrained analogs of CB-1 antagonists: 1,5,6,7-Tetrahydro-4H-pyrrolo[3,2-c]pyridine-4-one derivatives.
Smith RA, Fathi Z, Brown SE, Choi S, Fan J, Jenkins S, Kluender HC, Konkar A, Lavoie R, Mays R, Natoli J, O'Connor SJ, Ortiz AA, Podlogar B, Taing C, Tomlinson S, Tritto T, Zhang Z. Smith RA, et al. Among authors: fathi z. Bioorg Med Chem Lett. 2007 Feb 1;17(3):673-8. doi: 10.1016/j.bmcl.2006.10.095. Epub 2006 Nov 2. Bioorg Med Chem Lett. 2007. PMID: 17107792
58 results