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Page 1
Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity.
Rudolph J, Esler WP, O'connor S, Coish PD, Wickens PL, Brands M, Bierer DE, Bloomquist BT, Bondar G, Chen L, Chuang CY, Claus TH, Fathi Z, Fu W, Khire UR, Kristie JA, Liu XG, Lowe DB, McClure AC, Michels M, Ortiz AA, Ramsden PD, Schoenleber RW, Shelekhin TE, Vakalopoulos A, Tang W, Wang L, Yi L, Gardell SJ, Livingston JN, Sweet LJ, Bullock WH. Rudolph J, et al. Among authors: bierer de. J Med Chem. 2007 Oct 18;50(21):5202-16. doi: 10.1021/jm070071+. Epub 2007 Sep 21. J Med Chem. 2007. PMID: 17887659
SAR of a novel 'Anthranilamide Like' series of VEGFR-2, multi protein kinase inhibitors for the treatment of cancer.
Wickens P, Kluender H, Dixon J, Brennan C, Achebe F, Bacchiocchi A, Bankston D, Bierer D, Brands M, Braun D, Brown MS, Chuang CY, Dumas J, Enyedy I, Hofilena G, Hong Z, Housley T, Jones B, Khire U, Kreiman C, Kumarasinghe E, Lowinger T, Ott-Morgan R, Perkins L, Phillips B, Schoenleber R, Scott WJ, Sheeler R, Redman A, Sun X, Taylor I, Wang L, Wilhelm S, Zhang X, Zhang M, Sullivan E, Carter C, Miglarese M, Levy J. Wickens P, et al. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4378-81. doi: 10.1016/j.bmcl.2007.02.075. Epub 2007 Mar 3. Bioorg Med Chem Lett. 2007. PMID: 17574417
Ethnobotanical-directed discovery of the antihyperglycemic properties of cryptolepine: its isolation from Cryptolepis sanguinolenta, synthesis, and in vitro and in vivo activities.
Bierer DE, Fort DM, Mendez CD, Luo J, Imbach PA, Dubenko LG, Jolad SD, Gerber RE, Litvak J, Lu Q, Zhang P, Reed MJ, Waldeck N, Bruening RC, Noamesi BK, Hector RF, Carlson TJ, King SR. Bierer DE, et al. J Med Chem. 1998 Mar 12;41(6):894-901. doi: 10.1021/jm9704816. J Med Chem. 1998. PMID: 9526563
Novel antihyperglycemic terpenoid-quinones from Pycnanthus angolensis.
Fort DM, Ubillas RP, Mendez CD, Jolad SD, Inman WD, Carney JR, Chen JL, Ianiro TT, Hasbun C, Bruening RC, Luo J, Reed MJ, Iwu M, Carlson TJ, King SR, Bierer DE, Cooper R. Fort DM, et al. Among authors: bierer de. J Org Chem. 2000 Oct 6;65(20):6534-9. doi: 10.1021/jo000568q. J Org Chem. 2000. PMID: 11052098
Total Synthesis of Cacalol.
Garofalo AW, Litvak J, Wang L, Dubenko LG, Cooper R, Bierer DE. Garofalo AW, et al. Among authors: bierer de. J Org Chem. 1999 Apr 30;64(9):3369-3372. doi: 10.1021/jo9822838. J Org Chem. 1999. PMID: 11674448 No abstract available.
32 results