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Construction and biological characterization of artificial recombinants between a wild type flavivirus (Kunjin) and a live chimeric flavivirus vaccine (ChimeriVax-JE).
Pugachev KV, Schwaiger J, Brown N, Zhang ZX, Catalan J, Mitchell FS, Ocran SW, Rumyantsev AA, Khromykh AA, Monath TP, Guirakhoo F. Pugachev KV, et al. Among authors: rumyantsev aa. Vaccine. 2007 Sep 17;25(37-38):6661-71. doi: 10.1016/j.vaccine.2007.07.016. Epub 2007 Jul 27. Vaccine. 2007. PMID: 17693000
Single-dose vaccine against tick-borne encephalitis.
Rumyantsev AA, Goncalvez AP, Giel-Moloney M, Catalan J, Liu Y, Gao QS, Almond J, Kleanthous H, Pugachev KV. Rumyantsev AA, et al. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13103-8. doi: 10.1073/pnas.1306245110. Epub 2013 Jul 15. Proc Natl Acad Sci U S A. 2013. PMID: 23858441 Free PMC article.
The neurovirulence and neuroinvasiveness of chimeric tick-borne encephalitis/dengue virus can be attenuated by introducing defined mutations into the envelope and NS5 protein genes and the 3' non-coding region of the genome.
Engel AR, Rumyantsev AA, Maximova OA, Speicher JM, Heiss B, Murphy BR, Pletnev AG. Engel AR, et al. Among authors: rumyantsev aa. Virology. 2010 Sep 15;405(1):243-52. doi: 10.1016/j.virol.2010.06.014. Epub 2010 Jul 1. Virology. 2010. PMID: 20594569 Free PMC article.
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