Sudakin V - Search Results

1

Targeting mitosis for anti-cancer therapy.

Sudakin V, Yen TJ. Sudakin V, et al. BioDrugs. 2007;21(4):225-33. doi: 10.2165/00063030-200721040-00003. BioDrugs. 2007. PMID: 17628120 Review.

2

Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC.

Chan GK, Jablonski SA, Sudakin V, Hittle JC, Yen TJ. Chan GK, et al. Among authors: sudakin v. J Cell Biol. 1999 Sep 6;146(5):941-54. doi: 10.1083/jcb.146.5.941. J Cell Biol. 1999. PMID: 10477750 Free PMC article.

3

Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2.

Sudakin V, Chan GK, Yen TJ. Sudakin V, et al. J Cell Biol. 2001 Sep 3;154(5):925-36. doi: 10.1083/jcb.200102093. J Cell Biol. 2001. PMID: 11535616 Free PMC article.

4

Conformation-dependent ligand regulation of ATP hydrolysis by human KSP: activation of basal hydrolysis and inhibition of microtubule-stimulated hydrolysis by a single, small molecule modulator.

Luo L, Carson JD, Molnar KS, Tuske SJ, Coales SJ, Hamuro Y, Sung CM, Sudakin V, Auger KR, Dhanak D, Jackson JR, Huang PS, Tummino PJ, Copeland RA. Luo L, et al. Among authors: sudakin v. J Am Chem Soc. 2008 Jun 18;130(24):7584-91. doi: 10.1021/ja710889h. Epub 2008 May 21. J Am Chem Soc. 2008. PMID: 18491908

5

ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism.

Luo L, Parrish CA, Nevins N, McNulty DE, Chaudhari AM, Carson JD, Sudakin V, Shaw AN, Lehr R, Zhao H, Sweitzer S, Lad L, Wood KW, Sakowicz R, Annan RS, Huang PS, Jackson JR, Dhanak D, Copeland RA, Auger KR. Luo L, et al. Among authors: sudakin v. Nat Chem Biol. 2007 Nov;3(11):722-6. doi: 10.1038/nchembio.2007.34. Epub 2007 Oct 7. Nat Chem Biol. 2007. PMID: 17922005

6

Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity.

Chaturvedi P, Sudakin V, Bobiak ML, Fisher PW, Mattern MR, Jablonski SA, Hurle MR, Zhu Y, Yen TJ, Zhou BB. Chaturvedi P, et al. Among authors: sudakin v. Cancer Res. 2002 Mar 15;62(6):1797-801. Cancer Res. 2002. PMID: 11912157

7

Structure-based design of potent and selective 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitors.

Medina JR, Becker CJ, Blackledge CW, Duquenne C, Feng Y, Grant SW, Heerding D, Li WH, Miller WH, Romeril SP, Scherzer D, Shu A, Bobko MA, Chadderton AR, Dumble M, Gardiner CM, Gilbert S, Liu Q, Rabindran SK, Sudakin V, Xiang H, Brady PG, Campobasso N, Ward P, Axten JM. Medina JR, et al. Among authors: sudakin v. J Med Chem. 2011 Mar 24;54(6):1871-95. doi: 10.1021/jm101527u. Epub 2011 Feb 22. J Med Chem. 2011. PMID: 21341675

8

The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis.

Sudakin V, Ganoth D, Dahan A, Heller H, Hershko J, Luca FC, Ruderman JV, Hershko A. Sudakin V, et al. Mol Biol Cell. 1995 Feb;6(2):185-97. doi: 10.1091/mbc.6.2.185. Mol Biol Cell. 1995. PMID: 7787245 Free PMC article.

9

Purification of the mitotic checkpoint complex (MCC) and the anaphase promoting complex/cyclosome (APC/C) from HeLa cells.

Sudakin V. Sudakin V. Cold Spring Harb Protoc. 2010 Jun;2010(6):pdb.prot5449. doi: 10.1101/pdb.prot5449. Cold Spring Harb Protoc. 2010. PMID: 20516187

10

Purification of the mitotic checkpoint complex, an inhibitor of the APC/C from HeLa cells.

Sudakin V, Yen TJ. Sudakin V, et al. Methods Mol Biol. 2004;281:199-212. doi: 10.1385/1-59259-811-0:199. Methods Mol Biol. 2004. PMID: 15220531

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