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Role of Cdk5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson's disease.
Qu D, Rashidian J, Mount MP, Aleyasin H, Parsanejad M, Lira A, Haque E, Zhang Y, Callaghan S, Daigle M, Rousseaux MW, Slack RS, Albert PR, Vincent I, Woulfe JM, Park DS. Qu D, et al. Among authors: rousseaux mw. Neuron. 2007 Jul 5;55(1):37-52. doi: 10.1016/j.neuron.2007.05.033. Neuron. 2007. PMID: 17610816 Free article.
The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage.
Aleyasin H, Rousseaux MW, Phillips M, Kim RH, Bland RJ, Callaghan S, Slack RS, During MJ, Mak TW, Park DS. Aleyasin H, et al. Among authors: rousseaux mw. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18748-53. doi: 10.1073/pnas.0709379104. Epub 2007 Nov 14. Proc Natl Acad Sci U S A. 2007. PMID: 18003894 Free PMC article.
DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway.
Aleyasin H, Rousseaux MW, Marcogliese PC, Hewitt SJ, Irrcher I, Joselin AP, Parsanejad M, Kim RH, Rizzu P, Callaghan SM, Slack RS, Mak TW, Park DS. Aleyasin H, et al. Among authors: rousseaux mw. Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3186-91. doi: 10.1073/pnas.0914876107. Epub 2010 Jan 26. Proc Natl Acad Sci U S A. 2010. PMID: 20133695 Free PMC article.
Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics.
Irrcher I, Aleyasin H, Seifert EL, Hewitt SJ, Chhabra S, Phillips M, Lutz AK, Rousseaux MW, Bevilacqua L, Jahani-Asl A, Callaghan S, MacLaurin JG, Winklhofer KF, Rizzu P, Rippstein P, Kim RH, Chen CX, Fon EA, Slack RS, Harper ME, McBride HM, Mak TW, Park DS. Irrcher I, et al. Among authors: rousseaux mw. Hum Mol Genet. 2010 Oct 1;19(19):3734-46. doi: 10.1093/hmg/ddq288. Epub 2010 Jul 16. Hum Mol Genet. 2010. PMID: 20639397
Regulation of the VHL/HIF-1 pathway by DJ-1.
Parsanejad M, Zhang Y, Qu D, Irrcher I, Rousseaux MW, Aleyasin H, Kamkar F, Callaghan S, Slack RS, Mak TW, Lee S, Figeys D, Park DS. Parsanejad M, et al. Among authors: rousseaux mw. J Neurosci. 2014 Jun 4;34(23):8043-50. doi: 10.1523/JNEUROSCI.1244-13.2014. J Neurosci. 2014. PMID: 24899725 Free PMC article.
DJ-1 interacts with and regulates paraoxonase-2, an enzyme critical for neuronal survival in response to oxidative stress.
Parsanejad M, Bourquard N, Qu D, Zhang Y, Huang E, Rousseaux MW, Aleyasin H, Irrcher I, Callaghan S, Vaillant DC, Kim RH, Slack RS, Mak TW, Reddy ST, Figeys D, Park DS. Parsanejad M, et al. Among authors: rousseaux mw. PLoS One. 2014 Sep 11;9(9):e106601. doi: 10.1371/journal.pone.0106601. eCollection 2014. PLoS One. 2014. PMID: 25210784 Free PMC article.
38 results