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Cigarette smoke and its component acrolein augment IL-8/CXCL8 mRNA stability via p38 MAPK/MK2 signaling in human pulmonary cells.
Moretto N, Bertolini S, Iadicicco C, Marchini G, Kaur M, Volpi G, Patacchini R, Singh D, Facchinetti F. Moretto N, et al. Among authors: patacchini r. Am J Physiol Lung Cell Mol Physiol. 2012 Nov 15;303(10):L929-38. doi: 10.1152/ajplung.00046.2012. Epub 2012 Sep 14. Am J Physiol Lung Cell Mol Physiol. 2012. PMID: 22983351 Free article. Clinical Trial.
Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents.
Andrè E, Campi B, Materazzi S, Trevisani M, Amadesi S, Massi D, Creminon C, Vaksman N, Nassini R, Civelli M, Baraldi PG, Poole DP, Bunnett NW, Geppetti P, Patacchini R. Andrè E, et al. Among authors: patacchini r. J Clin Invest. 2008 Jul;118(7):2574-82. doi: 10.1172/JCI34886. J Clin Invest. 2008. PMID: 18568077 Free PMC article.
Novel class of benzoic acid ester derivatives as potent PDE4 inhibitors for inhaled administration in the treatment of respiratory diseases.
Armani E, Amari G, Rizzi A, De Fanti R, Ghidini E, Capaldi C, Carzaniga L, Caruso P, Guala M, Peretto I, La Porta E, Bolzoni PT, Facchinetti F, Carnini C, Moretto N, Patacchini R, Bassani F, Cenacchi V, Volta R, Amadei F, Capacchi S, Delcanale M, Puccini P, Catinella S, Civelli M, Villetti G. Armani E, et al. Among authors: patacchini r. J Med Chem. 2014 Feb 13;57(3):793-816. doi: 10.1021/jm401549m. Epub 2014 Jan 29. J Med Chem. 2014. PMID: 24400806
TRP functions in the broncho-pulmonary system.
De Logu F, Patacchini R, Fontana G, Geppetti P. De Logu F, et al. Among authors: patacchini r. Semin Immunopathol. 2016 May;38(3):321-9. doi: 10.1007/s00281-016-0557-1. Epub 2016 Apr 15. Semin Immunopathol. 2016. PMID: 27083925 Review.
Acetaminophen, via its reactive metabolite N-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents.
Nassini R, Materazzi S, Andrè E, Sartiani L, Aldini G, Trevisani M, Carnini C, Massi D, Pedretti P, Carini M, Cerbai E, Preti D, Villetti G, Civelli M, Trevisan G, Azzari C, Stokesberry S, Sadofsky L, McGarvey L, Patacchini R, Geppetti P. Nassini R, et al. Among authors: patacchini r. FASEB J. 2010 Dec;24(12):4904-16. doi: 10.1096/fj.10-162438. Epub 2010 Aug 18. FASEB J. 2010. PMID: 20720158
TRP channels.
Benemei S, Patacchini R, Trevisani M, Geppetti P. Benemei S, et al. Among authors: patacchini r. Curr Opin Pharmacol. 2015 Jun;22:18-23. doi: 10.1016/j.coph.2015.02.006. Epub 2015 Mar 2. Curr Opin Pharmacol. 2015. PMID: 25725213 Review.
202 results