Ohtaka H - Search Results

1

Compensating enthalpic and entropic changes hinder binding affinity optimization.

Lafont V, Armstrong AA, Ohtaka H, Kiso Y, Mario Amzel L, Freire E. Lafont V, et al. Among authors: ohtaka h. Chem Biol Drug Des. 2007 Jun;69(6):413-22. doi: 10.1111/j.1747-0285.2007.00519.x. Chem Biol Drug Des. 2007. PMID: 17581235

2

Multidrug resistance to HIV-1 protease inhibition requires cooperative coupling between distal mutations.

Ohtaka H, Schön A, Freire E. Ohtaka H, et al. Biochemistry. 2003 Nov 25;42(46):13659-66. doi: 10.1021/bi0350405. Biochemistry. 2003. PMID: 14622012

3

Overcoming drug resistance in HIV-1 chemotherapy: the binding thermodynamics of Amprenavir and TMC-126 to wild-type and drug-resistant mutants of the HIV-1 protease.

Ohtaka H, Velázquez-Campoy A, Xie D, Freire E. Ohtaka H, et al. Protein Sci. 2002 Aug;11(8):1908-16. doi: 10.1110/ps.0206402. Protein Sci. 2002. PMID: 12142445 Free PMC article.

4

Structural and thermodynamic basis of resistance to HIV-1 protease inhibition: implications for inhibitor design.

Velazquez-Campoy A, Muzammil S, Ohtaka H, Schön A, Vega S, Freire E. Velazquez-Campoy A, et al. Among authors: ohtaka h. Curr Drug Targets Infect Disord. 2003 Dec;3(4):311-28. doi: 10.2174/1568005033481051. Curr Drug Targets Infect Disord. 2003. PMID: 14754432 Review.

5

Thermodynamic rules for the design of high affinity HIV-1 protease inhibitors with adaptability to mutations and high selectivity towards unwanted targets.

Ohtaka H, Muzammil S, Schön A, Velazquez-Campoy A, Vega S, Freire E. Ohtaka H, et al. Int J Biochem Cell Biol. 2004 Sep;36(9):1787-99. doi: 10.1016/j.biocel.2004.02.021. Int J Biochem Cell Biol. 2004. PMID: 15183345 Review.

6

Adaptive inhibitors of the HIV-1 protease.

Ohtaka H, Freire E. Ohtaka H, et al. Prog Biophys Mol Biol. 2005 Jun;88(2):193-208. doi: 10.1016/j.pbiomolbio.2004.07.005. Prog Biophys Mol Biol. 2005. PMID: 15572155 Free article. Review.

7

Isothermal titration calorimetry.

Velázquez-Campoy A, Ohtaka H, Nezami A, Muzammil S, Freire E. Velázquez-Campoy A, et al. Among authors: ohtaka h. Curr Protoc Cell Biol. 2004 Sep;Chapter 17:Unit 17.8. doi: 10.1002/0471143030.cb1708s23. Curr Protoc Cell Biol. 2004. PMID: 18228446 Review.

8

National trends in the outcomes of subarachnoid haemorrhage and the prognostic influence of stroke centre capability in Japan: retrospective cohort study.

Kurogi R, Kada A, Ogasawara K, Nishimura K, Kitazono T, Iwama T, Matsumaru Y, Sakai N, Shiokawa Y, Miyachi S, Kuroda S, Shimizu H, Yoshimura S, Osato T, Horie N, Nagata I, Nozaki K, Date I, Hashimoto Y, Hoshino H, Nakase H, Kataoka H, Ohta T, Fukuda H, Tamiya N, Kurogi AI, Ren N, Nishimura A, Arimura K, Shimogawa T, Yoshimoto K, Onozuka D, Ogata S, Hagihara A, Saito N, Arai H, Miyamoto S, Tominaga T, Iihara K; J-ASPECT Study Collaborators. Kurogi R, et al. BMJ Open. 2023 Apr 10;13(4):e068642. doi: 10.1136/bmjopen-2022-068642. BMJ Open. 2023. PMID: 37037619 Free PMC article.

9

Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016.

Kurogi A, Onozuka D, Hagihara A, Nishimura K, Kada A, Hasegawa M, Higashi T, Kitazono T, Ohta T, Sakai N, Arai H, Miyamoto S, Sakamoto T, Iihara K; J-ASPECT Study Collaborators. Kurogi A, et al. Sci Rep. 2022 Feb 28;12(1):3252. doi: 10.1038/s41598-022-06074-1. Sci Rep. 2022. PMID: 35228551 Free PMC article.

10

Effect of Vesicle Size on the Cytolysis of Cell-Penetrating Peptides (CPPs).

Sakamoto K, Kitano T, Kuwahara H, Tedani M, Aburai K, Futaki S, Abe M, Sakai H, Ohtaka H, Yamashita Y. Sakamoto K, et al. Among authors: ohtaka h. Int J Mol Sci. 2020 Oct 7;21(19):7405. doi: 10.3390/ijms21197405. Int J Mol Sci. 2020. PMID: 33036492 Free PMC article.

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