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Bortezomib-induced sensitization of malignant human glioma cells to vorinostat-induced apoptosis depends on reactive oxygen species production, mitochondrial dysfunction, Noxa upregulation, Mcl-1 cleavage, and DNA damage.
Premkumar DR, Jane EP, Agostino NR, DiDomenico JD, Pollack IF. Premkumar DR, et al. Among authors: agostino nr. Mol Carcinog. 2013 Feb;52(2):118-33. doi: 10.1002/mc.21835. Epub 2011 Nov 15. Mol Carcinog. 2013. PMID: 22086447 Free PMC article.
ABT-737 synergizes with bortezomib to induce apoptosis, mediated by Bid cleavage, Bax activation, and mitochondrial dysfunction in an Akt-dependent context in malignant human glioma cell lines.
Premkumar DR, Jane EP, DiDomenico JD, Vukmer NA, Agostino NR, Pollack IF. Premkumar DR, et al. Among authors: agostino nr. J Pharmacol Exp Ther. 2012 Jun;341(3):859-72. doi: 10.1124/jpet.112.191536. Epub 2012 Mar 5. J Pharmacol Exp Ther. 2012. PMID: 22393246 Free PMC article.