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Formation of an adduct between insulin and the toxic lipoperoxidation product acrolein decreases both the hypoglycemic effect of the hormone in rat and glucose uptake in 3T3 adipocytes.
Medina-Navarro R, Guzmán-Grenfell AM, Díaz-Flores M, Duran-Reyes G, Ortega-Camarillo C, Olivares-Corichi IM, Hicks JJ. Medina-Navarro R, et al. Among authors: hicks jj. Chem Res Toxicol. 2007 Oct;20(10):1477-81. doi: 10.1021/tx7001355. Epub 2007 Sep 6. Chem Res Toxicol. 2007. PMID: 17803267
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