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Page 1
A structural biology view of target drugability.
Egner U, Hillig RC. Egner U, et al. Among authors: hillig rc. Expert Opin Drug Discov. 2008 Apr;3(4):391-401. doi: 10.1517/17460441.3.4.391. Expert Opin Drug Discov. 2008. PMID: 23489095
Structure of wild-type Plk-1 kinase domain in complex with a selective DARPin.
Bandeiras TM, Hillig RC, Matias PM, Eberspaecher U, Fanghänel J, Thomaz M, Miranda S, Crusius K, Pütter V, Amstutz P, Gulotti-Georgieva M, Binz HK, Holz C, Schmitz AA, Lang C, Donner P, Egner U, Carrondo MA, Müller-Tiemann B. Bandeiras TM, et al. Among authors: hillig rc. Acta Crystallogr D Biol Crystallogr. 2008 Apr;64(Pt 4):339-53. doi: 10.1107/S0907444907068217. Epub 2008 Mar 19. Acta Crystallogr D Biol Crystallogr. 2008. PMID: 18391401
Crystallization and molecular-replacement solution of a diagnostic fluorescent dye in complex with a specific Fab fragment.
Hillig RC, Baesler S, Urlinger S, Stark Y, Bauer S, Badock V, Huber M, Bahr I, Schirner M, Licha K. Hillig RC, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Mar 1;63(Pt 3):217-23. doi: 10.1107/S1744309107005957. Epub 2007 Feb 23. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007. PMID: 17329818 Free PMC article.
Discovery of BAY-985, a Highly Selective TBK1/IKKε Inhibitor.
Lefranc J, Schulze VK, Hillig RC, Briem H, Prinz F, Mengel A, Heinrich T, Balint J, Rengachari S, Irlbacher H, Stöckigt D, Bömer U, Bader B, Gradl SN, Nising CF, von Nussbaum F, Mumberg D, Panne D, Wengner AM. Lefranc J, et al. Among authors: hillig rc. J Med Chem. 2020 Jan 23;63(2):601-612. doi: 10.1021/acs.jmedchem.9b01460. Epub 2020 Jan 10. J Med Chem. 2020. PMID: 31859507
Design and synthesis of macrocyclic inhibitors of phosphatase cdc25B.
Bäurle S, Blume T, Günther J, Henschel D, Hillig RC, Husemann M, Mengel A, Parchmann C, Schmid E, Skuballa W. Bäurle S, et al. Among authors: hillig rc. Bioorg Med Chem Lett. 2004 Apr 5;14(7):1673-7. doi: 10.1016/j.bmcl.2004.01.052. Bioorg Med Chem Lett. 2004. PMID: 15026048
A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy.
Böhnke N, Berger M, Griebenow N, Rottmann A, Erkelenz M, Hammer S, Berndt S, Günther J, Wengner AM, Stelte-Ludwig B, Mahlert C, Greven S, Dietz L, Jörißen H, Barak N, Bömer U, Hillig RC, Eberspaecher U, Weiske J, Giese A, Mumberg D, Nising CF, Weinmann H, Sommer A. Böhnke N, et al. Among authors: hillig rc. Bioconjug Chem. 2022 Jun 15;33(6):1210-1221. doi: 10.1021/acs.bioconjchem.2c00178. Epub 2022 Jun 3. Bioconjug Chem. 2022. PMID: 35658441 Free PMC article.
Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRASG12C.
Mortier J, Friberg A, Badock V, Moosmayer D, Schroeder J, Steigemann P, Siegel F, Gradl S, Bauser M, Hillig RC, Briem H, Eis K, Bader B, Nguyen D, Christ CD. Mortier J, et al. Among authors: hillig rc. ChemMedChem. 2020 May 19;15(10):827-832. doi: 10.1002/cmdc.201900727. Epub 2020 Apr 1. ChemMedChem. 2020. PMID: 32237114 Free PMC article.
35 results