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Not all hERG pore domain mutations have a severe phenotype: G584S has an inactivation gating defect with mild phenotype compared to G572S, which has a dominant negative trafficking defect and a severe phenotype.
Zhao JT, Hill AP, Varghese A, Cooper AA, Swan H, Laitinen-Forsblom PJ, Rees MI, Skinner JR, Campbell TJ, Vandenberg JI. Zhao JT, et al. Among authors: campbell tj. J Cardiovasc Electrophysiol. 2009 Aug;20(8):923-30. doi: 10.1111/j.1540-8167.2009.01468.x. Epub 2009 Apr 10. J Cardiovasc Electrophysiol. 2009. PMID: 19490267
Kinetics of drug interaction with the Kv11.1 potassium channel.
Hill AP, Perrin MJ, Heide J, Campbell TJ, Mann SA, Vandenberg JI. Hill AP, et al. Among authors: campbell tj. Mol Pharmacol. 2014 May;85(5):769-76. doi: 10.1124/mol.114.091835. Epub 2014 Feb 28. Mol Pharmacol. 2014. PMID: 24586056
156 results